摘要
Abstract
Objective To explore the diagnostic value of peripheral blood heparin binding protein(HBP),amyloid A(SAA)and immature granulocyte percentage(IG%)levels in the diagnosis of acute pancreatitis(AP),so as to providing a reference basis for clinical diagnosis and treatment.Methods A total of 121 AP pa-tients treated in this hospital from June 2021 to August 2023 were selected as the research objects,who were divided into the mild AP group(MAP group,n=63),the moderate-severe AP group(MSAP group,n=36)and the severe AP group(SAP group,n=22)according to the severity of the disease,meanwhile 80 cases of healthy medical checkups in the same period of time in this hospital were selected as the control group.Clinical data and peripheral blood HBP,SAA levels and IG%of the study subjects in each group were compared.The Spearman correlation analysis was adopted to analyze the correlation of HBP,SAA and IG%levels with the severity of AP.The diagnostic value of peripheral blood HBP,SAA and IG%for early AP was assessed by plotting the receiver operating characteristic(ROC)curve.Results The clinical data of the four groups showed no statistically significant difference(P>0.05).The levels of HBP and SAA in the SAP group>the MSAP group>the MAP group>the control group,and the difference between any two groups was statisti-cally significant(P<0.05).The IG%in the SAP group and the MSAP group were higher than those in the MAP group and the control group,and the IG%level in the SAP group was higher than that in the MSAP group,with statistically significant differences(P<0.05),but the difference in IG%between the MAP group and the control group was not statistically significant(P>0.05).Spearman's correlation analysis showed that HBP,SAA levels and IG%were all positively correlated with severity of AP(P<0.05).The results of the ROC curve showed that the area under the curve(AUC)for diagnosing AP of peripheral blood HBP,SAA,IG%,HBP+SAA and HBP+SAA+IG%were 0.700(95%CI:0.627-0.773),0.787(95%CI:0.726-0.848),0.460(95%CI:0.378-0.542),0.850(95%CI:0.792-0.907)and 0.860(95%CI:0.811-0.908),respectively.Conclusion The combined detection of peripheral blood HBP and SAA has high diagnostic value for AP,while IG%is of little value;the combined detection of peripheral blood HBP,SAA and IG%is helpful to clinically assess the severity of AP,especially valuable for predicting MSAP and SAP.关键词
肝素结合蛋白/淀粉样蛋白A/未成熟粒细胞百分率/急性胰腺炎/诊断Key words
heparin binding protein/amyloid A/immature granulocytes percentage/acute pancreati-tis/diagnosis分类
医药卫生
