摘要
Abstract
Objective To investigate the effects of distribution of pathogenic bacteria in the alveolar lavage fluid of patients with severe pulmonary infections and its effect on inflammatory factors and lung function.Methods A total of 100 patients with severe pulmonary infection admitted to Weinan Maternal and Child Health Hospital from May 2020 to May 2022 were selected as study subjects,and all patients received bron-choalveolar lavage examination.The distribution of pathogenic bacteria,the level of microinflammatory factors[including interleukin-6(IL-6),interleukin-8(IL-8),interleukin-10(IL-10),tumor necrosis factor(TNF-α)],pulmonary function index[one-second expiratory volume(FEV1)/predicted value,FEV1/forced vital capacity(FVC)]and the severity of pulmonary infection[evaluated by the Clinical Pulmonary Infection Score(CPIS)]of the patients with severe pulmonary infections were analyzed.Results The alveolar lavage fluid of 100 pa-tients with severe pulmonary infections was cultured with pathogenic bacteria media,and a total of 100 strains of pathogenic bacteria were detected,including 50 strains of Gram-negative bacteria(50.00%)as Gram-nega-tive bacteria group,41 strains of Gram-positive bacteria(41.00%)as Gram-positive bacteria group,and 9 strains of fungi(9.00%)as fungal group.The levels of IL-6,IL-8,IL-10 and TNF-α in the Gram-negative bac-teria group were higher than those in the Gram-positive bacteria group and fungus group(P<0.05),and the levels of IL-6,IL-8,IL-10 and TNF-α in the Gram-positive bacteria group were higher than those in the fungus group(P<0.05).The FEV1/predictive value and FEV1/FVC in the Gram-negative bacteria group were lower than those in the Gram-positive bacteria group and fungi group,while the CPRIS score was higher in the Gram-positive bacteria group than that in the Gram-positive bacteria group and the fungi group,with statisti-cally significant differences(P<0.05);and the FEV1/predicted value and FEV1/FVC in the Gram-positive bacteria group were lower than those in the fungi group,while the CPRIS score in the Gram-positive bacteria group was higher than that in the fungi group,with statistically significant differences(P<0.05).Conclusion Gram-nega-tive bacteria is the most prevalent in patients with severe pulmonary infection,followed by Gram-positive bac-teria and fungi;patients infected with gram-negative bacteria have the highest levels of inflammatory factors,the most severe lung infections,and the poorest lung function.关键词
肺部感染/肺泡灌洗液/病原菌/炎症因子/肺功能Key words
pulmonary infection/bronchoalveolar lavage fluid/pathogenic bacteria/inflammatory factor/pulmonary function分类
医药卫生
