摘要
Abstract
Objective To explore the value of serum ionized calcium(iCa)in the evaluation of neonatal sepsis.Methods The clinical data of 83 neonates with sepsis who met the inclusion criteria and were admitted to the First Affiliated Hospital of Gannan Medical University from July 2019 to March 2022 were retrospec-tively analyzed.According to the severity of the disease,the patients were divided into sepsis group(53 cases)and severe sepsis group(30 cases).The differences of iCa,C-reactive protein(CRP)and albumin(ALB)lev-els were compared between the sepsis group and the severe sepsis group.Pearson correlation was used to ana-lyze the correlation of iCa levels with ALB,CRP levels and NCIS score.Results Comparison of iCa,ALB and CRP levels between the sepsis group and severe sepsis group showed statistically significant differences(Z=-5.169,P<0.001;t=2.225,P =0.029;t'=-11.655,P<0.001).Pearson correlation analysis results showed that iCa level was positively correlated with ALB level and NCIS score(r=0.445,P<0.001;r= 0.480,P<0.001)and negatively correlated with CRP level(r=-0.537,P<0.001).According to the defi-nition of iCa based on the definition of neonatal hypocalcemia,83 neonates with sepsis were divided into 57 ca-ses in the iCa≥1.0 mmol/L group and 26 cases in the iCa<1.0 mmol/L group,and the differences of ALB,CRP levels and critical grades of the disease between the two groups were statistically significant(t=3.859,P<0.001;Z=-4.605,P<0.001;Z=-3.741,P<0.001).Conclusion iCa level is correlated with the se-verity of neonatal sepsis,negatively correlated with critical grades of the disease and CRP level,and positively correlated with ALB.The more severe the condition,the lower the level of iCa.关键词
离子钙/新生儿脓毒症/清蛋白/C-反应蛋白Key words
ionized calcium/neonatal sepsis/albumin/C-reactive protein分类
医药卫生
