摘要
Abstract
Objective To investigate the relationship between CD28,CD117,chemokine ligand 12(CXCL12)and extramedullary infiltration in patients with multiple myeloma and the assessment value of prognosis,so as to provide reference for early clinical intervention.Methods Ninety-six patients with multiple myeloma who attended the hospital from May 2020 to May 2022 were selected as the study subjects,which were divided into the occurrence group and the non-occurrence group according to whether or not the extr-amedullary infiltration occurred,and the clinical data and expressions of CD28,CD117 and CXCL12 in the two groups were compared,the relationship between the expression of CD28,CD117,and CXCL12 and extramedul-lary infiltration in patients with multiple myeloma were analyzed.After 6-month follow-up,the expressions of CD28,CD117 and CXCL12 in patients with different prognosis were compared,and their evaluation value of CD28,CD117 and CXCL12 for the prognosis of multiple myeloma were analyzed.Results Among 96 patients with multiple myeloma,extramedullary infiltration occurred in 38 cases(occurrence group)and the rest 58 ca-ses were non-occurrence group.The proportions of patients with positive CD28,CD117 and CXCL12 in the oc-currence group were higher than those in the non-occurrence group(P<0.05),and multivariate Logistic re-gression analysis showed that the positive expressions of CD28,CD117 and CXCL12 were all independent risk factors for extramedullary infiltration in patients with multiple myeloma(P<0.05).After 6 months of fol-low-up,21 patients died,and the proportions of positive expressions of CD28,CD117 and CXCL12 in died pa-tients were higher than those in survival patients(P<0.05).The risk of death in multiple myeloma patients with positive expressions of CD28,CD117 and CXCL12 was 7.091,29.231 and 20.143 times higher than that in multiple myeloma patients with negative expressions of CD28,CD117 and CXCL12,respectively(P<0.05).Conclusion Positive expressions of CD28,CD117 and CXCL12 can be used to evaluate extramedullary infiltration in multiple myeloma patients,providing reference for early clinical prognosis prediction,so as to carry out targeted follow-up treatment and improve prognosis.关键词
多发性骨髓瘤/髓外浸润/预后/CD28/CD117/趋化因子配体12Key words
multiple myeloma/extramedullary infiltration/prognosis/CD28/CD117/chemokine ligand 12分类
医药卫生
