检验医学与临床2024，Vol.21Issue(9)：1332-1335,1340,5.DOI:10.3969/j.issn.1672-9455.2024.09.031
免疫调节机制在免疫性血小板减少症中的研究进展
Research progress of immunomodulatory mechanisms in immune thrombocytopenia
摘要
Abstract
Immune thrombocytopenia(ITP)is a rare hematological disease,belonging to acquired autoim-mune disease.Immune disorders are the main cause,and its pathogenesis is getting more and more attention.Current studies have shown that the indicators including the production of autoantiplatelet antibodies,imbal-ance of Th1/Th2 and Th17/Tregs,high proliferation and low apoptosis of cytotoxic T lymphocytes,reduced number and dysfunction of Bregs cells,apoptosis,heredity and autophagy play a key role in the pathogenesis of ITP.This paper reviews various complex mechanisms involved in the pathogenesis of ITP that have been dis-covered in recent years from the above six aspects,with the aim of providing a more comprehensive understanding of the factors affecting the development of ITP and providing new ideas and targets for the treatment of ITP.关键词
免疫性血小板减少症/自身抗体/细胞自噬/血小板/免疫Key words
immune thrombocytopenia/autoantibodies/autophagy/platelet/immunity分类
医药卫生引用本文复制引用
徐小凡,李一鸣,徐小虎,代义龙,金呈强..免疫调节机制在免疫性血小板减少症中的研究进展[J].检验医学与临床,2024,21(9):1332-1335,1340,5.基金项目
山东省自然科学基金资助项目(ZR2010HL038、ZR20219BH050) （ZR2010HL038、ZR20219BH050）
山东省医药卫生科技发展计划项目(2017WS223) （2017WS223）
山东省高等学校科技计划项目(J15LL11) （J15LL11）
山东省中医药科技发展计划项目(2015-244) （2015-244）
济宁医学院教师科研扶持基金(JYFC2018FKJ096). （JYFC2018FKJ096）
