国际眼科杂志2024，Vol.24Issue(5)：697-703,7.DOI:10.3980/j.issn.1672-5123.2024.5.07
玻璃体腔注射雷珠单抗与康柏西普治疗早产儿视网膜病变疗效比较
Comparison of intravitreal injection of Ranibizumab versus Conbercept in the treatment of retinopathy of prematurity
摘要
Abstract
AIM:To compare the efficacy of intravitreal injection of ranibizumab(IVR)and intravitreal injection of conbercept(IVC)in children with retinopathy of prematurity(ROP). METHODS:Retrospective study.A total of 1 100 eyes with ROP treated with intravitreal anti-VEGF at our hospital from January 2015 to June 2023 were included.According to the different therapeutic drugs,the children were divided into two groups:IVR group and IVC group.According to the degree of ROP,the patients were divided into three groups:aggressive ROP(A-ROP),Zone Ⅰtype 1 ROP and Zone Ⅱ type 1 ROP.The reactivation and retreatment between the two groups were compared after propensity score matching(PSM)analysis,and they were followed-up for at least 3 mo after surgery. RESULTS:In Zone Ⅱ type 1 ROP,there was a statistically significant difference in the rates of reactivation and retreatment between the IVR and IVC groups(P＜0.05);however,in A-ROP and Zone Ⅰ type 1 ROP,there were no statistically significant differences in the rates of reactivation and retreatment between the two groups(P＞0.05).The risk of reactivation and retreatment of Zone Ⅰ type 1 ROP was higher than the Zone Ⅱ type 1 ROP.Furthermore,the use of drugs and corrected gestational age of first treatment were influencing factors of lesion recurrence and retreatment. CONCLUSION:There is a significant difference in the initial cure effect between the two drugs in Zone Ⅱ type 1 ROP,with the reactivation and retreatment rates of the IVC group being much lower than those of the IVR group.关键词
早产儿视网膜病变/雷珠单抗/康柏西普/疗效Key words
retinopathy of prematurity/Ranibizumab/Conbercept/efficacy引用本文复制引用
陈娟,罗先琼,张韫琦,谢素贞,任建兵,李静,聂川,梁志江,何其祯,黄学林..玻璃体腔注射雷珠单抗与康柏西普治疗早产儿视网膜病变疗效比较[J].国际眼科杂志,2024,24(5):697-703,7.基金项目
广东省基础与应用基础研究基金项目(No.2019A1515011417) （No.2019A1515011417）
广东省医学科学技术研究基金项目(No.A2022221) Guangdong Basic and Applied Basic Research Foundation(No.2019A1515011417) （No.A2022221）
Guangdong Provincial Medical Science and Technology Research Foundation(No.A2022221) （No.A2022221）
