国际眼科杂志2024，Vol.24Issue(5)：790-794,5.DOI:10.3980/j.issn.1672-5123.2024.5.24
复方樟柳碱联合视网膜激光光凝治疗重度非增殖性糖尿病视网膜病变
Compound anisodine combined with retinal laser photocoagulation for the treatment of severe non-proliferative diabetic retinopathy
摘要
Abstract
AIM:To investigate the clinical efficacy of the compound anisodine combined with retinal laser photocoagulation in the treatment of severe non-proliferative diabetic retinopathy(NPDR). METHODS:According to the retrospective study,totally 120 eyes of patients with severe NPDR who admitted to Daxing Teaching Hospital Affiliated to Capital Medical University from May 2023 to July 2023 were selected.The patients were divided into the observation group and the control group according to treatment methods,with 60 eyes in each group.The observation group was treated with panretinal photocoagulation combined with the compound anisodine injection.The control group was only treated with panretinal photocoagulation.The optical coherence tomography angiography(OCTA)and optical coherence tomography(OCT)were used to quantitatively analyze the fundus retinal structure and blood flow.Furthermore,the best corrected visual acuity(BCVA),superficial vascular density(SVD),deep vascular density(DVD),choroidal blood flow density and central macular foveal retinal thickness(CMT)were compared before treatment and at 1 d,1 and 2 mo after treatment. RESULTS:At 2 mo postoperatively,the rate of visual improvement and the BCVA in the observation group of patients were significantly better than those of the control group,and the incidence of macular edema in the observation group was significantly lower than the control group(P＜0.05).The BCVA at 1 and 2 mo after treatment were significantly higher than those before treatment in both groups(P＜0.05).The SVD in the observation group was better than the control group at 1 d,1 and 2 mo after treatment(all P＜0.05).The DVD and choroidal flow density in the observation group were better than those of the control group at 1 d after treatment(all P＜0.05).The CMT of the observation group was smaller than that of the control group at 1 d after treatment(P＜0.05). CONCLUSION:Compound anisodine can effectively improve the fundus microcirculation after panretinal photocoagulation and reduce the incidence of macular edema,thus promoting the visual function.关键词
复方樟柳碱/重度非增殖性糖尿病视网膜病变/光学相干断层扫描血流成像/黄斑水肿/全视网膜激光光凝Key words
compound anisodine/severe non-proliferative diabetic retinopathy/optical coherence tomography angiography/macular edema/panretinal photocoagulation引用本文复制引用
安鑫,焦剑,魏文斌,张茉莉..复方樟柳碱联合视网膜激光光凝治疗重度非增殖性糖尿病视网膜病变[J].国际眼科杂志,2024,24(5):790-794,5.基金项目
国家自然科学基金(No.82220108017,82141128) （No.82220108017,82141128）
首都卫生发展科研专项(No.首发2020-1-2052) （No.首发2020-1-2052）
北京市科委科技计划项目(No.Z201100005520045,Z181100001818003) （No.Z201100005520045,Z181100001818003）
首都医科大学大兴教学医院院内课题(No.4202320476) National Natural Science Foundation of China(No.82220108017,82141128) （No.4202320476）
The Capital Health Research and Development of Special(No.2020-1-2052) （No.2020-1-2052）
Science & Technology Project of Beijing Municipal Science & Technology Commission(No.Z201100005520045,Z181100001818003) （No.Z201100005520045,Z181100001818003）
Project of Daxing Teaching Hospital(No.4202320476) （No.4202320476）
