老年医学与保健2024，Vol.30Issue(2)：290-296,7.
老年人肌肉减少症与心房颤动之间因果关联的孟德尔随机化分析
Mendelian randomization analysis of causal relationship between sarcopenia and atrial fibrillation in the elderly
摘要
Abstract
Objective This study used mendelian randomization(MR)to investigate the causal relationship between sarcopenia and the risk of atrial fibrillation,providing a theoretical basis for the prevention and treatment of atrial fibrillation in elderly.Methods Based on the dataset from the Genome Wide Association Study(GWAS),the characteristic indicators of sarcopenia including left hand grip strength,right hand grip strength,and appendicular lean mass(ALM)were used as the ex-posure factors for sarcopenia,and AF were used as the outcome.The causal effects of left hand grip strength,right hand grip strength and ALM on AF were evaluated by MR.Results The results of the inverse variance weighted(IVW)analysis showed that left hand grip strength(OR = 0.782,95%CI:0.677～0.904,P＜0.001),right hand grip strength(OR = 0.646,95%CI:0.558～0.748,P＜0.001),and ALM(OR =0.769,95%CI:0.739～0.799,P＜0.001)were associated with a reduced risk of AF,and there was no heterogeneity or validity in the results.Conclusion An increase in left hand grip strength,right hand grip strength,and ALM may be useful for prevent and treat AF.关键词
肌肉减少症/心房颤动/孟德尔随机化/衰老Key words
sarcopenia/atrial fibrillation/Mendelian randomization/aging引用本文复制引用
申涛,黄璨,陈泽娥,欧阳昆富,葛建军,韩振..老年人肌肉减少症与心房颤动之间因果关联的孟德尔随机化分析[J].老年医学与保健,2024,30(2):290-296,7.基金项目
深圳市自然科学基金(JCYJ20210324110012034 （）
JCYJ20220531093814032) （）
深港脑科学创新研究院项目(2023SHIBS0004) （2023SHIBS0004）
