老年医学与保健2024，Vol.30Issue(2)：315-319,335,6.
沙库巴曲缬沙坦联用达格列净对老年慢性心力衰竭患者心肾功能的影响
Effects of sacubitril/valsartan combined with dapagliflozin on cardiac and renal function in elderly patients with chronic heart failure
摘要
Abstract
Objective To observe the clinical therapeutic effects of sacubitril/valsartan combined with dapagliflozin on elderly patients with chronic heart failure.Methods A total of 271 elderly patients with chronic heart failure treated in Depart-ment of Cardiology of Huadong Hospital Affiliated to Fudan University from July 2018 to October 2022 were retrospectively se-lected.Among them,there were 89 cases in treatment group 1 treated with valsartan alone,90 ones in treatment group 2 treated with sacubitril/valsartan,and 92 ones in treatment group 3 treated with sacubitril valsartan combined with dapagliflozin.All three groups were treated continuously for 12(10-13.5)months.The levels of serum creatinine,uric acid,left ventricular end-diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF)and brain natriuretic peptide(BNP)were compared among the three groups before and after treatment.Results After 12(10-13.5)months of treatment,the clinical effective rate of the treatment group3 was95.7%,which was significantly higher than that of the treatment group 1(80.9%)(P＜0.05).Compared with before treatment,the cardiac function indexes in all groups were significantly improved,and renal func-tion indexes in the treatment group3 were significantly improved(P＜0.05).In terms of LVEF improvement,the treatment group 3 and treatment group 2 were superior to the treatment group 1.In terms of LVEDD,serum creatinine,and uric acid im-provement,the treatment group 3 was superior to the treatment group 2 and treatment group 1.In terms of BNP improvement,the treatment group 3 was superior to the treatment group 1.All the above results were statistically significant(P＜0.05).Conclusion All three treatment regimens can improve the cardiac and renal function indicators in elderly patients with chronic heart failure.However,compared to the use of valsartan alone or sacubactril/valsartan,the combination of sacubitril/valsartan with dapagliflozin in the treatment of elderly patients with chronic heart failure has the greatest cardiac and renal benefits.关键词
沙库巴曲缬沙坦/达格列净/老年/慢性心力衰竭Key words
sacubitril/valsartan/dapagliflozin/elderly/chronic heart failure引用本文复制引用
田佳文,朱菲白,陈梦伟,马潇泓,翁婷雯..沙库巴曲缬沙坦联用达格列净对老年慢性心力衰竭患者心肾功能的影响[J].老年医学与保健,2024,30(2):315-319,335,6.基金项目
上海市级医院老年医学科临床能力促进与提升专科联盟项目(SHDC22023302) （SHDC22023302）
