高龄慢性阻塞性肺疾病患者心电图特征与肺功能及实验室指标的相关性OACSTPCD

Objective To analyze the correlation between electrocardiogram(ECG)characteristics and lung function and laboratory indexes in elderly patients with chronic obstructive pulmonary disease(COPD).Methods The clinical data of 120 elderly COPD patients admitted to General Hospital of Western Theater Command from October 2018 to October 2023 were retrospectively analyzed.According to the COPD stage,they were divided into stable group(n =72)and acute exacerbation group(n =48).Baseline data,clinical signs,pulmonary function indexes,laboratory indexes and ECG characteristics of the two groups were observed and compared.The correlation between ECG characteristic detection value and lung function indexes and experimental indexes was analyzed.Results Among 120 elderly COPD patients,there were 72 cases in the stable stage(stable stage group)and 48 ones in the acute exacerbation stage(acute exacerbation group).The age of the stable stage group was significantly younger than that of the acute exacerbation phase group(P＜0.05),but there was no statistically significant difference in baseline data such as gender,BMI,alcohol consumption,and smoking between the two groups(P＜0.05).The incidence of pulmonary infection and clinical signs observed on pulmonary CT(emphysema and bullosa)in the stable stage group were significantly lower than those in the acute exacerbation stage group(P＜0.05).There were no significant differ-ences in the first symptoms and pulmonary signs between the two groups(P＞0.05).FeNO level of the stable stage group was significantly lower than that of the acute exacerbation group(P＜0.05),while FVC and FEV1 values were significantly higher than those of the acute exacerbation group(P＜0.05).The levels of WBC,CRP,PaCO2,IL-6,IgE and TNF-a of the stable stage group were significantly lower than those of the acute exacerbation stage group(P＜0.05),but there was no statistical significance in PaO2 level and pH value between the two groups(P＞0.05).The P wave axis,P wave time,QRS wave axis and I-lead QRS wave amplitudes of the stable stage group were significantly lower/shorter than those of the acute exacerbation stagegroup(P＜0.05),but there were no significant differences in other index values(P＞0.05).P wave axis,P wave time,QRS wave axis and I-lead QRS amplitude were correlated with the levels of FeNO,CRP,PaCO2,IL-6,IgE and TNF-a.FVC,FEV1 and WBC were not correlated with the P wave axis and P wave time,but were correlated with the QRS wave axis and the I-lead QRS wave amplitude.Conclusion The clinical manifestations and ECG changes in elderly patients with acute exacerbation are different from those in elderly patients with stable COPD.Attention should be paid to age,lung function,rele-vant laboratory indexes,and ECG of patients to effectively control the progression of COPD.