临床眼科杂志2024，Vol.32Issue(2)：107-111,5.DOI:10.3969/j.issn.1006-8422.2024.02.003
低浓度阿托品联合角膜塑形镜对低中度近视青少年裸眼视力、角膜曲率、球镜度数的影响
Effects of low-concentration atropine combined with orthokeratology on uncorrected visual acuity,corneal curvature and spherical equivalent in adolescents with low to moderate myopia
摘要
Abstract
Objective To explore the effects of low-concentration atropine combined with orthokeratology on uncorrected visual acuity UCVA,corneal curvature and spherical equivalent in adolescents with low to moderate myopia.Methods A prospective case-control study.A total of 90 adolescent patients with low to moderate myopia from August 2020 to January 2023were enrolled.According to the random number table method,they were divided into the atropine group,orthokeratology group and combination group,30 cases in each group.The atropine group was treated with low-concentration atropine,the orthokeratology group was treated with orthokeratology,and the combination group was treated with low-concentration atropine and orthokeratology.The changes of UCVA,corneal curvature,spherical equivalent,intraocular pressure,ocular axial length,diopter and corneal endothelium before and after the treatment were observed and compared among the three groups.The incidence of adverse reactions was statistically analyzed.Results After the treatment,corneal curvature and spherical equivalent in the combination group were lower than those in the orthokeratology group and atropine group,while UCVA was higher than that in the orthokeratology group and atropine group(F=17.980、F=5.192、F=29.760、P<0.05).After the treatment,the intraocular pressure,ocular axial length and diopter in the combination group were lower than those in the orthokeratology group and atropine group(F=3.667、F=18.731、F=5.118、P<0.05).There was no significant difference in corneal endothelial cell density(CD),hexagonal cell ratio(HEX)or coefficient of variation(CV)between the two groups before and after the treatment(P>0.05).There was no significant difference in the total incidence of adverse reactions among the two groups(P>0.05).Conclusions Low-concentration atropine combined with orthokeratology can effectively improve UCVA and diopter,enhance the control ability of axial length and intraocular pressure in adolescents with low to moderate myopia.There were no significant effects on corneal endothelial cells,with high safety.关键词
阿托品/角膜塑形镜/低中度近视Key words
Atropine/Orthokeratology/Low to moderate myopia引用本文复制引用
刘姗,刘璐,田沫,王海伟,岳岩坤..低浓度阿托品联合角膜塑形镜对低中度近视青少年裸眼视力、角膜曲率、球镜度数的影响[J].临床眼科杂志,2024,32(2):107-111,5.基金项目
北京市自然科学基金项目(7192080) （7192080）
北京市西城区优秀人才培养专项经费资助项目(202039) （202039）
