农业生物技术学报2024，Vol.32Issue(5)：1150-1168,19.DOI:10.3969/j.issn.1674-7968.2024.05.016
单细胞转录组测序技术及其在动物骨骼研究中的应用
Single-cell RNA Sequencing Technology and Its Application in Animal Bone Research
摘要
Abstract
The skeleton is an important part of the animal body,playing a vital role in providing biomechanical support,maintaining movement,hematopoiesis,and calcium homeostasis.The application of bulk RNA sequencing(bulk RNA-seq)technology in skeletal research has provided important references for revealing the development of bone cells,but it still has limitations in revealing the heterogeneity of bone cells.In recent years,the emerging single-cell RNA sequencing(scRNA-seq)technology has greatly improved the efficiency of cell capture and survival rate,allowing researchers to interpret biological information from the perspective of individual cells in a population of cells,providing a new research strategy for studying the heterogeneity of bone cells and the relationship between cell populations.This article reviewed the progress of single-cell RNA sequencing technology and its application in animal bone research,with the aim of providing reference for future studies.关键词
单细胞转录组测序(scRNA-seq)/动物骨骼/细胞异质性Key words
Single-cell RNA sequencing(scRNA-seq)/Animal bones/Cellular heterogeneity分类
农业科技引用本文复制引用
刘哲,田学凯,何玉琳,杨培钰,于太永..单细胞转录组测序技术及其在动物骨骼研究中的应用[J].农业生物技术学报,2024,32(5):1150-1168,19.基金项目
国家重点研发计划(2021YFD1301205) （2021YFD1301205）
