四川中医2024，Vol.42Issue(3)：112-116,5.
解毒抑瘤汤联合西医标准方案治疗基因突变阴性晚期非小细胞肺癌的疗效观察
The efficacy of JieduYiliu decoction combined with Western medicine standard regimen in the treatment of gene mutation negative advanced non-small cell lung cancer
摘要
Abstract
Objective:To observe the efficacy and toxicity of JieduYiliu decoction combined with Western medicine standard regimen in the treatment of gene mutation negative advanced non-small cell lung cancer(NSCLC)based on the pathogenesis the-ory of"cancer toxin-qi blood and body fluid".Methods:48NSCLC cases with negative gene mutations were randomly divided into the treatment group and the control group,with 24cases in each group.The control group was treated with a standard Western medicine regimen,while the treatment group was treated with the traditional Chinese medicine JieduYiliu decoction on the basis of the control group.After two consecutive cycles of treatment,evaluate the short-term efficacy,traditional Chinese medicine syn-drome efficacy,quality of life,Median progression free survival and toxic side effects.Results:Treatment group vs control group:Treatment effective rate:54.2％vs 45.8％;Disease control rate:83.3％vs 70.8％;The improvement rate of traditional Chinese medicine syndrome:87.5％vs 70.8％;KPS score:78.49±12.81points vs 69.32±13.94points;Median progression free sur-vival time:9.8months vs 6.2months.The treatment group was superior to the control group in terms of treatment effectiveness,disease control rate,improvement rate of traditional Chinese medicine syndrome,KPS score,and median progression free survival(P＜0.05).The incidence of nausea,vomiting,constipation,and anorexia in the treatment group was lower than that in the con-trol group(P＜0.05),and there was no statistically significant difference in the incidence of bone marrow suppression and liver and kidney damage between the treatment group and the control group(P＞0.05).Conclusions:JieduYiliu decoction can improve the short-term efficacy of Western medicine standard regimen in treating the advanced NSCLC with negative gene mutations,pro-long the survival time of patients,improve their traditional Chinese medicine syndromes and quality of life,and alleviate some chemotherapy related side effects,with good safety.关键词
解毒抑瘤汤/癌毒/气血津液/病机/疗效/非小细胞肺癌Key words
JieduYiliu decoction/Cancer toxin/Qi blood and body fluid/Pathogenesis/Efficacy/Non small cell lung cancer分类
医药卫生引用本文复制引用
杨万全,王恳,王红,龙文玲..解毒抑瘤汤联合西医标准方案治疗基因突变阴性晚期非小细胞肺癌的疗效观察[J].四川中医,2024,42(3):112-116,5.基金项目
四川省中医药管理局科学技术研究专项课题-中医药临床(编号:2023MS162). （编号:2023MS162）
