四川中医2024，Vol.42Issue(3)：133-136,4.
基于氧化应激及肾纤维化指标分析益气滋阴化瘀通络方治疗气阴两虚型IgA肾病的有效性
Based on oxidative stress and renal fibrosis indicators to analyze the effectiveness of Yiqi Ziyin Huayu Tongluo de-coction in the treatment of IgA nephropathy with deficiency of both qi and yin
摘要
Abstract
Objective:To analyze the effect of Yiqi Ziyin Huayu Tongluo Decoction in treating IgA nephropathy with deficien-cy of both Qi and Yin on oxidative stress indexes and renal fibrosis indexes.Methods:84patients with IgA nephropathy of Qi and Yin deficiency type were collected and randomly divided into a control group(42cases,basic treatment)and a research group(42cases,basic treatment+Yiqi Ziyin Huayu Tongluo prescription),and the efficacy was evaluated.The patient's cubital venous blood was measured for serum oxidative stress indicators.[malondialdehyde(MDA),superoxide dismutase(SOD)],renal fi-brosis indicators[hyaluronidase(HA),laminin(LN)],renal function indicators[blood urea nitrogen(BUN),serum creati-nine(Scr)],Adverse reactions such as dizziness,headache,nausea and vomiting,and lethargy were recorded during the treat-ment.Results:Compared with the total effective rate of treatment,the research group was significantly higher than the control group(P＜0.05);after treatment,the serum SOD level of the research group was higher than that of the control group,and the MDA level was lower than that of the control group(P＜0.05);HA and LN were significantly lower than those in the control group(P＜0.05);after treatment,the levels of BUN and Scr in the study group were significantly lower than those in the control group(P＜0.05);there was no significant difference in the total incidence of adverse reactions such as nausea,vomiting,and lethargy among the groups Scientific significance(P＞0.05).Conclusion:Using Yiqi Ziyin Huayu Tongluo Decoction to treat IgA nephropathy can reduce the oxidative stress response of patients,delay the process of renal fibrosis,improve renal function signifi-cantly,and have outstanding overall curative effect and high safety.关键词
IgA肾病/益气滋阴化瘀通络方/随机对照/氧化应激/肾纤维化Key words
IgA nephropathy/Yiqi Ziyin Huayu Tongluo Decoction/randomized control/oxidative stress/renal fibrosis分类
医药卫生引用本文复制引用
路博宇,唐晨思,张孝利,向广生..基于氧化应激及肾纤维化指标分析益气滋阴化瘀通络方治疗气阴两虚型IgA肾病的有效性[J].四川中医,2024,42(3):133-136,4.基金项目
河北省中医药管理局科研计划项目(编号:2019407). （编号:2019407）
