四川中医2024，Vol.42Issue(3)：140-144,5.
针刺联合黄芪桂枝五物汤对2型糖尿病周围神经病变的临床疗效及对患者微血管内皮细胞功能的影响
Clinical efficacy of acupuncture combined with Huangqi Guizhi Wuwu decoction on type 2diabetic peripheral neu-ropathy based on channels and collaterals theory and influence on microvascular endothelial cell function
摘要
Abstract
Objective:To explore the clinical efficacy of acupuncture combined with Huangqi Guizhi Wuwu decoction in the treatment of type 2diabetic peripheral neuropathy(DPN)based on channels and collaterals theory and the influence on microvas-cular endothelial cell function of patients.Methods:100 patients with DPN who received traditional Chinese medicine treatment in our hospital from August 2019 to December 2022 were selected as the study subjects.According to the complete randomization method,the study subjects were divided into 50 cases in study group and 50cases in control group.The control group was treated with acupoint acupuncture on the basis of conventional therapy,and the study group was given Huangqi Guizhi Wuwu decoction combined with acupoint acupuncture on the basis of conventional therapy.The difference in clinical efficacy after treatment and differences in blood glucose indicators[fasting plasma glucose(FPG),2h postprandial blood glucose(2hPG),glycosylated he-moglobin(HbA1c)],median nerve sensory nerve conduction velocity(SNCV)and motor nerve conduction velocity(MNCV),common peroneal nerve SNCV and MNCV,blood lipids[total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C)]and vascular endothelial cell function-related indicators[nitric oxide(NO),endothelin-1(ET-1),vascular endothelial growth factor(VEGF),brachial artery flow-mediated dilation(FMD),brachial artery nitroglycerin-mediated dilation(NMD)]before and after treatment were compared between both groups of patients,and the adverse reactions after treatment were observed.Results:After treatment,the total effective rate of clinical ef-ficacy in study group was significantly higher than that in control group(P＜0.05).The levels of FBG,2hBG,HbA1c,TC,TG,LDL-C,ET-1and VEGF in study group after treatment were lower than those before treatment,and were significantly lower than those in control group after treatment(P＜0.05).The SNCV and MNCV of median nerve and common peroneal nerve,HDL-C,NO,FMD and NMD were higher than those before treatment,and were significantly higher than after treatment in control group(P＜0.05).There were no obvious adverse reactions during treatment in both groups.Conclusion:Acupuncture combined with Huangqi Guizhi Wuwu Decoction in treating DPN based on channels and collaterals theory can significantly improve the blood glu-cose and blood lipids,accelerate the nerve conduction velocity,and regulate the microvascular endothelial cell function.关键词
脉络学说/针刺/黄芪桂枝五物汤/2型糖尿病/周围神经病变Key words
Channels and collaterals theory/Acupuncture/Huangqi Guizhi Wuwu decoction/Type 2diabetes/Peripheral neuropathy分类
医药卫生引用本文复制引用
杨娜,田皎丁,孟晶晶,曹亮..针刺联合黄芪桂枝五物汤对2型糖尿病周围神经病变的临床疗效及对患者微血管内皮细胞功能的影响[J].四川中医,2024,42(3):140-144,5.基金项目
河北省中医药管理局科研计划项目(编号:2021381),基于脉络学说探讨针刺联合黄芪桂枝五物汤对2型糖尿病周围神经病变的临床疗效及对患者微血管内皮细胞功能的影响). （编号:2021381）
