健脾和胃汤联合胃十针治疗脾胃不和型失眠临床研究OACSTPCD

Objective:To observe the effect of Jianpi Hewei decoction combined with Weishi acupuncture in the treatment of insomnia of spleen-stomach dispiritus and its influence on TCM syndrome score,serum factor levels and polysomnography parameters.Methods:120 patients with insomnia of spleen-stomach disharmony were randomly di-vided into control group(Weishi acupuncture therapy)and observation group(Jianpi Hewei decoction combined with Weishi acupuncture therapy),both groups were treated for 4 weeks.The TCM syndrome scores(tossing and turn-ing,easily waking up,eating less and stomach noise)were evaluated before and after treatment,the serum factor lev-els[noradrenaline(NE),5-hydroxytryptamine(5-HT)and brain-derived neurotrophic factor(BDNF)]were detec-ted,the Pittsburgh sleep quality index(PSQI)scores were evaluated,the polysomnography parameters were moni-tored,and the incidence of adverse reactions and total effective rate of treatment were calculated.Results:After treat-ment,the TCM syndrome scores(tossing and turning,easily waking up,eating less and stomach noise),PSQI scores,serum factors(NE,5-HT and BDNF)and polysomnography parameters(waking time,wakening times,sleep latency time and fast-wave sleep ratio)of the two groups were significantly improved(P<0.05),and the above indexes and total effective rate of treatment in the observation group were significantly better than those in the control group(P<0.05),but there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Jianpi Hewei decoction combined with Weishi acupuncture can effectively improve the TCM symp-toms of yawning in patients with insomnia of spleen-stomach disharmony,and the curative effect is better than that of Weishi acupuncture alone.Meanwhile,it can effectively regulate the levels of wake-promoting factor NE,sleep-promoting factor 5-HT and BDNF in serum neurotransmitters,improve sleep monitoring indexes,and it is safe and reliable.