陕西中医2024，Vol.45Issue(5)：700-703,4.DOI:10.3969/j.issn.1000-7369.2024.05.029
小针刀联合膝痹丸治疗寒湿痹阻型膝关节骨性关节炎临床研究
Clinical curative effect of small needle-knife combined with Xibi pill in knee osteoarthritis of cold-damp arthralgia syndrome
摘要
Abstract
Objective:To explore the curative effect of small needle-knife combined with Xibi pill in knee osteo-arthritis(KOA)of cold-damp arthralgia syndrome.Methods:According to simple random number table method,a to-tal of 104 patients with KOA were divided into observation group(52 cases)and control group(52 cases).The con-trol group was given oral celecoxib capsules,while observation group was treated with small needle-knife combined with Xibi pills on basis of control group for 8 weeks.After treatment,clinical curative effect,scores of TCM syn-dromes,visual analogue scale(VAS),Western Ontario and McMaster University Osteoarthritis Index(WOMAC)and arthroscopic knee surgery(AKS),levels of serum C-reactive protein(CRP),interleukin-6(IL-6),cartilage oligo-meric matrix protein(COMP)and collagen 2-1(Coll2-1)were compared.Adverse symptoms were recorded during the intervention.Results:The total response rate of observation group was better(94.23%vs 78.85%,P<0.05).After treatment,scores of TCM syndromes(joint swelling,joint pain,morning stiffness,poor joint movement)were decreased in both groups,which were lower in observation group than control group(P<0.05).After treatment,scores of VAS and WOMAC,levels of serum CRP and IL-6,COMP and Coll2-1 in joint fluid were all decreased in both groups,which were lower in observation group than control group(P<0.05),while AKS score was increased,which was higher in observation group(P<0.05).There was no significant difference in the incidence of adverse re-actions between the two groups(P>0.05).Conclusion:Curative effect of small needle-knife combined with Xibi pill is good in KOA of cold-damp arthralgia syndrome,which can relieve TCM syndrome and pain,reduce levels of bio-markers and inflammatory factors.关键词
湿痹阻型膝关节骨性关节炎/小针刀/膝痹丸/关节液聚基质蛋白/胶原蛋白2-1/炎症因子Key words
Knee osteoarthritis of cold-damp arthralgia syndrome/Small needle-knife/Xibi pill/Cartilage oli-gomeric matrix protein in joint fluid/Collagen 2-1/Inflammatory factor分类
医药卫生引用本文复制引用
张岭,杨帆,杨晓晓,杨洋,张成勇,刘陆勇..小针刀联合膝痹丸治疗寒湿痹阻型膝关节骨性关节炎临床研究[J].陕西中医,2024,45(5):700-703,4.基金项目
山东省中医药科技项目(M-2023298) （M-2023298）
