皮肤性病诊疗学杂志2024，Vol.31Issue(4)：219-225,7.DOI:10.3969/j.issn.1674-8468.2024.04.001
海分枝杆菌皮肤感染的临床和病理特点:附12例分析
Analyses of clinical and histopathological characteristics of twelve cases of cutaneous Myco-bacterium marinum infections
摘要
Abstract
Objective To analyze the clinical manifestations and histopathological features of cutaneous Mycobacterium marinum infections in order to improve the understanding,diagnosis and treatment of this disease.Methods We retrospectively analyzed the clinical manifestations,his-topathological features,treatment and outcome of 12 cases of cutaneous Mycobacterium marinum infections diagnosed at the Fifth Affiliated Hospital of Sun Yat-Sen University from 2020 to 2023.Results The average age was 47.3 years.Seafood-induced trauma was a risk factor.Clinical presentations often included unilateral distribution of multiple chronic nodules and plaques on the upper limb,resembling sporotrichosis.Pathological findings included epidermal acanthosis,der-mal non-specific inflammatory infiltration,and sometimes with tuberculosis-like granulomas.How-ever,the positive rate of acid-fast staining was low.Nine patients received anti-infective therapy consisting of clarithromycin combined with rifampicin or moxifloxacin.The treatment regimen for other three patients was unknown.All patients experienced resolution of their skin lesions without serious adverse drug reactions,and there were no recurrences during 1-year follow-up.Conclu-sions Mycobacterium marinum infection should be suspected in patients,especially middle-aged and elderly individuals with a history of trauma or handling seafood,presenting with chronic nod-ules and plaques,along with pathological findings of tuberculosis-like granuloma or non-specific inflammatory infiltration.These patients can be treated with clarithromycin and rifampicin.关键词
海分枝杆菌/皮肤感染/临床特征/病理特点Key words
Mycobacterium marinum/skin infection/clinical characteristics/pathologi-cal features引用本文复制引用
杨璐,李建建,刘婷,马寒,陈燕清..海分枝杆菌皮肤感染的临床和病理特点:附12例分析[J].皮肤性病诊疗学杂志,2024,31(4):219-225,7.基金项目
国家自然科学基金青年项目(82203936) （82203936）
广东省基础与应用基础研究基金区域联合基金青年基金项目(2021A1515110592) （2021A1515110592）
