皮肤性病诊疗学杂志2024，Vol.31Issue(4)：226-231,6.DOI:10.3969/j.issn.1674-8468.2024.04.002
司库奇尤单抗治疗儿童泛发性脓疱型银屑病临床分析
Clinical analysis of secukinumab in the treatment of childhood generalized pustular psoriasis
余敏 1应掌红2
作者信息
- 1. 南平市疾病预防控制中心,福建 南平 353000||福建医科大学附属第一医院,福建 福州 350005
- 2. 南平市疾病预防控制中心,福建 南平 353000
- 折叠
摘要
Abstract
Objective To explore the clinical efficacy and safety of secukinumab in the treat-ment of childhood generalized pustular psoriasis(GPP)in order to provide a new therapeutic strat-egy for childhood generalized pustular psoriasis.Methods A retrospective analysis was conducted on the clinical data of 25 children with GPP treated with subcutaneous secukinumab in our depart-ment from June 2020 to June 2022.The efficacy was evaluated according to Generalized Pustular Psoriasis Physician Global Assessment(GPPGA)scores,Generalized Pustular Psoriasis Area and Severity Index(GPPASI)scores,Children's Dermatology Life Quality Index(CDLQI)scores,and Depression Self-rating Scale for children(DSRSC)scores.The adverse reactions were also assessed.Results Following secukinumab treatments,the average time of lesion clearance was 3.36±0.99 days.Alleviations of scales and pustules were observed in majority of patients after 2-week treatment.After 28-week treatment,GPPGA score was reduced from 3.56±0.50 at baseline to 0.20±0.50,while GPPASI score was decreased from 34.83±9.24 at baseline to 0.68± 1.64.Similarly,both CDLQI and DSRSC scores were decreased 14.96±4.88 to 0.40±0.64 and 11.41±2.54 to 6.64±1.80,respectively.During the course of treatment,upper respiratory tract infections and eczema were observed in 2 cases each.One case each had pain with pruritus on the injection site and headache.No other adverse events were observed.Conclusions Secuki-numab is safe and can rapidly improve the erythema,scales and pustules in pediatric generalized pustular psoriasis in addition to the improvements in patients'quality of life and mental health.关键词
泛发性脓疱型银屑病/儿童/司库奇尤单抗Key words
generalized pustule psoriasis/pediatric/secukinumab引用本文复制引用
余敏,应掌红..司库奇尤单抗治疗儿童泛发性脓疱型银屑病临床分析[J].皮肤性病诊疗学杂志,2024,31(4):226-231,6.
