皮肤性病诊疗学杂志2024，Vol.31Issue(4)：237-245,9.DOI:10.3969/j.issn.1674-8468.2024.04.004
非受体酪氨酸激酶2可能是银屑病的潜在治疗靶点
PTPN2 can be a potential target for the treatment of psoriasis
摘要
Abstract
Objective To investigate the expression and regulatory mechanism of PTPN2 in psoriasis,and to analyze the effects of PTPN2 on psoriasis related immunity in order to determine whether PTPN2 can be used as a potential therapeutic target for psoriasis.Methods R language(3.6.3 version)was used to determine the difference in expression levels of PTPN2 between pso-riatic patients and controls,and the receiver operating characteristic(ROC)curve of PTPN2.The Gene Enrichment Analysis software(GSEA)and the Protein Interaction Analysis Database(STRING)were used to determine enrichment pathway of PTPN2 in the psoriasis dataset,and the interaction network of PTPN2 co-expressed genes.The distribution and expression of immune cells in psoriasis datasets were analyzed with CIBERSORT software.The differential expression of im-mune response pathways and immune response gene sets in psoriasis and their correlation with PT-PN2 were analyzed using R language(version 3.6.3).Results PTPN2 mRNA was highly ex-pressed in psoriatic lesions.Immune infiltrating cells,immune response pathways,and immune response gene sets were abnormal in psoriatic lesions.PTPN2 was associated with some immune infiltrating cells,immune response pathways,and immune response gene sets in psoriasis.Con-clusions PTPN2 mRNA is highly expressed in psoriatic lesions,and may participate in the oc-currence and development of psoriasis by regulating the immune microenvironment.关键词
PTPN2/免疫细胞浸润/免疫反应/银屑病Key words
PTPN2/immune cell infiltration/immune response/psoriasis引用本文复制引用
刘守刚,刘芳华,陈永锋..非受体酪氨酸激酶2可能是银屑病的潜在治疗靶点[J].皮肤性病诊疗学杂志,2024,31(4):237-245,9.基金项目
广东省医学科学技术研究基金(B2019121) （B2019121）
