摘要
Abstract
Objective:To observe the effect of modified Xiangsha Liujunzi and Shixiao San on TCM syndrome scores and re-currence in patients with peptic ulcer(PU)and spleen deficiency and liver stagnation syndrome.Methods:A total of 95patients with PU admitted to the hospital from January 2020to February 2022were selected and divided into th control group(48patients treated with omeprazole and rebamiprate)and the treatment group(47patients treated with modified Xiangsha Liujunzi and Shixi-ao San based on the treatment of control group).Clinical effects,TCM syndrome scores,gastric secretion function,intestinal bar-rier function,growth factors,adverse reactions and recurrence were compared between the two groups.Results:The treatment re-sponse rate in the treatment group was higher than that in the control group(97.87％vs.83.33％)(P＜0.05).After treatment,TCM syndrome scores of the two groups decreased.The scores for dull stomachache,pain relief during eating,swelling pain in chest and hypochondrium,poor appetite,limb burnout,intolerance of cold and cold limbs in the treatment group were lower than those in the control group(P＜0.05).After treatment,gastric secretion function[gastrin(GAS),pepsinogen(PG)-Ⅰ and PG-Ⅱ],intestinal barrier function[diamine oxidase(DAO),D-lactic acid and endotoxin(ET)]and growth factors[epider-mal growth factor(EGF),vascular endothelial growth factor(VEGF)and transforming growth factor-α(TGF-α)]in the two groups were significantly improved,with greater improvement in the treatment group(P＜0.05).The 1-year recurrence rate in the treatment group was lower than that in the control group(4.26％vs.18.75％)(P＜0.05).Conclusion:Modified Xiangsha Liujunzi and Shixiao San is effective in the treatment of PU with spleen deficiency and liver depression syndrome,which can ef-fectively improve clinical symptoms,gastric secretion function,intestinal barrier function and growth factors,and reduce the re-currence rate.关键词
消化性溃疡/脾虚肝郁证/香砂六君子合失笑散/中医证候积分/复发Key words
Peptic ulcer/Spleen deficiency and liver depression syndrome/Xiangsha Liujunzi and Shixiao San/TCM syn-drome score/Recurrence分类
医药卫生
