四川中医2024，Vol.42Issue(2)：141-145,5.
补阳还五汤加味联合依帕司他对气虚血瘀型糖尿病周围神经病变疗效及炎症因子、NRG1、Irisin的影响分析
Therapeutic effect of modified Buyang Huanwu Decoction combined with epalrestat on diabetic peripheral neuropa-thy of qi deficiency and blood stasis type and the influence on inflammatory factors,NRG 1and irisin
摘要
Abstract
Objective:To analyze the therapeutic effect of modified Buyang Huanwu Decoction combined with epalrestat on diabetic peripheral neuropathy of qi deficiency and blood stasis type,and the influence on inflammatory factors,neuregulin 1(NRG1)and irisin.Methods:A total of 100patients with diabetic peripheral neuropathy of qi deficiency and blood stasis type who were diagnosed and treated in the hospital from May 2021to December 2022were selected,and randomly divided into the con-trol group(50patients treated with epalrestat)and the observation group(50patients treated with modified Buyang Huanwu De-coction combined with epalrestat).Results:After treatment,symptom scores and the levels of interleukin-6(IL-6),IL-8,C-reactive protein(CRP)and NRG 1 in the observation group were lower than those in the control group,and the level of irisin was higher than that in the control group(P＜0.05).The improvement of motor nerve conduction velocity(MNCV)and sensory nerve conduction velocity(SNCV)of median nerve and common peroneal nerve in the observation group was better than that in the con-trol group(P＜0.05).The total clinical effective rate in the observation group was higher than that in the control group(P＜0.05).Conclusion:Modified Buyang Huanwu Decoction combined with epalrestat is markedly effective in the treatment patients with diabetic peripheral neuropathy of qi deficiency and blood stasis type.The combined treatment can improve the symptoms of qi deficiency and blood stasis,NRG1and irisin levels and nerve conduction velocity,and lower the levels of inflammatory factors.关键词
补阳还五汤加味/依帕司他/气虚血瘀/糖尿病周围神经病变/炎症因子Key words
Modified Buyang Huanwu Decoction/Epalrestat/Qi deficiency and blood stasis/Diabetic peripheral neuropa-thy/Inflammatory factor分类
医药卫生引用本文复制引用
宋丹,白洪超,陆平..补阳还五汤加味联合依帕司他对气虚血瘀型糖尿病周围神经病变疗效及炎症因子、NRG1、Irisin的影响分析[J].四川中医,2024,42(2):141-145,5.基金项目
安徽省中医药传承创新科研项目(编号:2020ccyb01). （编号:2020ccyb01）
