海南热带海洋学院学报2024，Vol.31Issue(2)：113-119,7.DOI:10.13307/j.issn.2096-3122.2024.02.16
密斑刺鲀鱼皮胶原蛋白对UVB诱导小鼠皮肤急性光损伤的保护作用
Protective Effect of Collagen from Diodon Hystrix Skin on UVB-induced Acute Skin Photodamage in Mice
潘梦 1彭竞一 2宋宇 2崔俊宇 3罗娜 2李卓男 2周佳锘 2钟小刚 2温志腾 2陈浩 2王珂珂2
作者信息
- 1. 海南热带海洋学院热带海洋生物资源利用与保护教育部重点实验室,海南 三亚 572022||海南热带海洋学院海南热带海洋渔业资源保护与利用重点实验室,海南 三亚 572022||海南热带海洋学院水产与生命学院,海南 三亚 572022||吉林大学 生命科学学院,长春 130012
- 2. 海南热带海洋学院热带海洋生物资源利用与保护教育部重点实验室,海南 三亚 572022||海南热带海洋学院海南热带海洋渔业资源保护与利用重点实验室,海南 三亚 572022||海南热带海洋学院水产与生命学院,海南 三亚 572022
- 3. 海南热带海洋学院热带海洋生物资源利用与保护教育部重点实验室,海南 三亚 572022||海南热带海洋学院海南热带海洋渔业资源保护与利用重点实验室,海南 三亚 572022||海南热带海洋学院水产与生命学院,海南 三亚 572022||长春中医药大学针灸推拿学院,长春 130117
- 折叠
摘要
Abstract
To explore the protective effect of Diodon hystrix skin collagen(DHSC)on UVB-induced acute skin photo-damage in mice,Balb/c mice were divided into control group(CTL),model group(MOD),low dose DHSC group(L),me-dium dose DHSC group(M),high dose DHSC group(H),matrix control group(B),and positive control group(Y).Skin acute photodamage model was established by UVB induction method.At the end of the experiment,the effect of DHSC on the back skin of mice was observed and scored by the double blind erythema.The effect of DHSC on skin histopathology was observed by HE staining.The structure of collagen in the tissue was observed by Masson staining.The activity of super-oxide dismutase(SOD)and the content of malondialdehyde(MDA)in the tissue were detected by colorimetry.The results showed that DHSC could effectively alleviate the UVB radiation-induced changes of skin appearance,tissue structure and collagen tissue in mice,and exhibited the protective effect on acute light injury of mice's skin by inhibiting the reduction of antioxidant enzyme activity and reducing the accumulation of lipid peroxide.关键词
密斑刺鲀/胶原蛋白/紫外线B/皮肤急性光损伤/保护作用Key words
Diodon hystrix/collagen/UVB/acute skin photodamage/protective effect分类
生物科学引用本文复制引用
潘梦,彭竞一,宋宇,崔俊宇,罗娜,李卓男,周佳锘,钟小刚,温志腾,陈浩,王珂珂..密斑刺鲀鱼皮胶原蛋白对UVB诱导小鼠皮肤急性光损伤的保护作用[J].海南热带海洋学院学报,2024,31(2):113-119,7.
