口腔颌面外科杂志2024，Vol.34Issue(2)：150-153,4.DOI:10.12439/kqhm.1005-4979.2024.02.013
免疫细胞对骨髓间充质干细胞成骨分化作用及机制的研究进展
Research progress on the effect and mechanism of immune cells on osteogenic differentiation of bone marrow mesenchymal stem cells
摘要
Abstract
The role of bone marrow mesenchymal stem cells(BMSCs)in bone defect repair and bone regeneration has been extensively studied.Much evidence suggests that effective endogenous bone regeneration requires coordination of the immune system.The interaction between immune cells and BMSCs is crucial to promoting bone formation in the healing of bone defects.In recent years,it has been found that a variety of immune cells promote osteogenic differentiation of BMSCs through the release of cytokines and signals.It is beneficial to bone defect repair and bone regeneration,and becomes a new therapeutic target for bone defect repair.Therefore,this article reviews the research status of the osteogenic effect of immune cells on BMSCs and related mechanisms.关键词
骨髓间充质干细胞/免疫细胞/成骨分化/骨缺损修复和骨再生Key words
bone marrow mesenchymal stem cells/immune cell/osteogenic differentiation/bone defect repair and bone regeneration分类
医药卫生引用本文复制引用
石琰,郭昊,郑凯娟,杨镇鸣,强金彪,史册..免疫细胞对骨髓间充质干细胞成骨分化作用及机制的研究进展[J].口腔颌面外科杂志,2024,34(2):150-153,4.基金项目
国家自然科学基金(81970903、82270959) （81970903、82270959）
