基于PI3K/PKB信号通路变化探究清胰汤在急性胰腺炎相关性肺损伤治疗中的应用价值及作用机制OACSTPCD
Exploration on the application value and action mechanism of Qingyi Decoction in the treatment of acute pancreati-tis related lung injury based on changes of PI3K/PKB signaling pathways
目的:基于磷脂酰肌醇3羟激酶(PI3K)/磷酸化蛋白激酶B(PKB)信号通路变化探究清胰汤在急性胰腺炎相关性肺损伤治疗中的应用价值及作用机制.方法:选取2020年8月～2022年11月我院收治的98例急性胰腺炎相关性肺损伤患者,随机分为对照组与观察组各49例,对照组给予常规西药治疗,观察组在对照组基础上加用中药清胰汤治疗,均治疗2周,比较两组患者的临床疗效,肠胃恢复状况(发热、腹胀腹痛、恶心呕吐及肠鸣音恢复时间),血氧指标[血氧分压(PaO2)、氧合指数(OI)水平],血清学指标[淀粉酶(AMY)、脂肪酶(LPS)、PI3K、PKB水平],生活质量[生活质量核心问卷(QLQ-C30)评分]以及不良反应发生情况.结果:治疗后,观察组患者的总有效率为91.84％高于对照组的73.47％(P＜0.05);观察组患者恶心呕吐、腹胀腹痛、发热、肠鸣音等肠胃状况恢复时间均短于对照组(P＜0.05);观察组患者的PaO2、O1水平均高于对照组(P＜0.05);观察组患者的血清AMY、LPS、PI3K、PKB水平均低于对照组(P＜0.05);观察组患者的QLQ-C30评分低于对照组(P＜0.05);两组患者均未见有明显严重不良反应发生,且两组间不良反应发生率比较无统计学差异(P＞0.05).结论:清胰汤对急性胰腺炎相关性肺损伤有较好的临床治疗效果,可有效缓解患者症状,提高生活质量,用药安全性好,PI3K/PKB信号通路激活被抑制是其主要作用机制之一.
Objective:To explore the application value and action mechanism of Qingyi Decoction in the treatment of acute pancreatitis related lung injury based on the changes of phosphatidylinositol 3-kinases(PI3K)/phosphorylated protein kinase B(PKB)signaling pathways.Methods:A total of 98patients with acute pancreatitis related lung injury admitted to the hospital were enrolled and randomly divided into control group and study group between August 2020and November 2022,49cases in each group.The control group was treated with routine western medicine,while study group was additionally treated with Qingyi Decoc-tion.Both were treated for 2weeks.The clinical curative effect,gastrointestinal recovery(fever,abdominal distension and pain,nausea and vomiting,bowel sound),blood oxygen indexes[oxygen partial pressure(PaO2),oxygenation index(OI)],sero-logical indexes[amylase(AMY),lipase(LPS),P13K,PKB],quality of life[Core Quality of Life Questionnaire(QLQ-C30)]and occurrence of adverse reactions in the two groups were compared.Results:After treatment,total response rate in study group was higher than that in control group(91.84％vs 73.47％,P＜0.05).The recovery time of gastrointestinal symptoms(fever,abdominal distension and pain,nausea and vomiting,bowel sound)in study group was shorter than that in control group(P＜0.05),levels of PaO2 and OI were higher than those in control group(P＜0.05),levels of AMY,LPS,PI3K and PKB were lower than those in control group(P＜0.05),and QLQ-C30score was lower than that in control group(P＜0.05).There were no significant serious adverse reactions in either group,and there was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion:The clinical curative effect of Qingyi Decoction is good on acute pancreatitis re-lated lung injury,which can effectively relieve symptoms and improve quality of life,with high medication safety.The inhibition of PI3K/PKB signaling pathways activation is one of the main mechanisms of action.
胡艾
安庆市中医院,安徽安庆 246000
临床医学
清胰汤急性胰腺炎相关性肺损伤磷脂酰肌醇3羟激酶/磷酸化蛋白激酶B信号通路
Qingyi Decoctionacute pancreatitisRelated lung injuryPhosphatidylinositol 3-kinases/phosphorylated pro-tein kinase BSignaling pathway
《四川中医》 2024 (003)
97-100 / 4
安庆市卫生健康委员会重点专科(专病)建设项目(编号:2019.12).
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