柴枳和胃胶囊对功能性消化不良肝郁脾虚证模型大鼠胃排空及胃肠激素的影响OACSTPCD

Objective:To investigate the potential mechanism of Chaizhi Hewei capsule in the treatment of func-tional dyspepsia with liver depression and spleen deficiency syndrome from gastric emptied.Methods:Sixty SD rats were randomly divided into modeling group(n=50)and blank group(n=10).The rat model of functional dyspepsia with liver depression and spleen deficiency was established by the combination of limited nutrition method and tail-clamping stimulation method.The effects of this product on body weight,water quantity,food intake,serum contents of NO,SS,MTL,gastric emptied and isolated gastric muscle strip activity of the model rats were investigated.Results:This product can reduce the contents of NO and SS in serum,increase the content of MTL,improve the gas-tric empties rate of FD model rats,improve the motion amplitude of isolated gastric muscle strips,increase the amount of food and increase body weight.Conclusion:This product has obvious improvement effect on functional dys-pepsia rat model with liver depression and spleen deficiency,and the mechanism may be realized by changing the con-tents of neurotransmitters SS,NO and MTL in serum.