扶正解秽汤联合重组人干扰素治疗慢性宫颈炎合并高危型HPV感染临床研究OACSTPCD

Objective:To observe the clinical efficacy of Fuzheng Jiehui decoction combined with recombinant human interferon in the treatment of chronic cervicitis complicated with high-risk human papillomavirus(HPV)in-fection.Methods:A total of 160 patients with chronic cervicitis and high-risk HPV infection were enrolled,randomly divided into two groups:the control group(80 cases)was treated with recombinant human interferonα-2b gel sup-positories intravaginally,and the observation group(80 cases)were treated with Fuzheng Jiehui decoction on the ba-sis of Fuzheng Jiehui decoction,and the course of treatment was 3 months.The clinical efficacy of the two groups was recorded,and the changes of TCM symptom score,cervicitis score and HPV viral load were compared between the two groups before and after treatment,and the time for vaginal discharge to return to normal,the healing time of cer-vical erosion surface and the rate of HPV conversion to negative were recorded.The changes of cellular immunity in-dexes and cervical local immune microenvironment were compared between the two groups.The recurrence rate and adverse reactions were recorded in the two groups.Results:The total effective rate of the observation group was 95.00%,which was significantly higher than control group(76.25%)(P<0.05).Compared with those before treatment,the TCM symptom score,cervicitis score,HPV viral load,serum CD8+ and interleukin-10(IL-10)levels of vaginal lavage fluid were significantly decreased after treatment in both groups(P<0.05),and those indexes in observation group were lower than control group(P<0.05).After treatment,and the serum CD3+,CD4+,CD4+/CD8+ ratio,sIgA in the vaginal lavage solution,and IL-2 was significantly increased(P<0.05),and those indexes in obser-vation group were higher than control group(P<0.05).The healing time of cervical erosion and vaginal discharge in observation group were shorter than control group,rate of HPV conversion was higher than control group(P<0.05).The recurrence rate of observation group was lower than control group after 6 months of treatment,and there was no significant difference in incidence of adverse reactions between the both(P>0.05).Conclusion:On the basis of recombinant human interferon therapy,the addition of Fuzheng Jiehui decoction can significantly improve the symptoms,improve the treatment efficacy,reduce the viral load,increase the rate of HPV conversion and reduce the recurrence rate in patients with chronic cervicitis and high-risk HPV infection,and the mechanism may be related to the regulation of body cellular immunity and the improvement of the local immune microenvironment of the cervix.