眼科学报2024，Vol.39Issue(1)：19-26,8.DOI:10.12419/24021801
息肉状脉络膜血管病变发生大出血的危险因素和治疗进展
Risk factors and treatment progress in massive hemorrhage secondary to polypoidal choroidal vasculopathy
摘要
Abstract
Polypoidal choroidal vasculopathy(PCV)is a common blinding disease in Asian populations.Massive hemorrhage complications secondary to PCV includes subretinal hemorrhage(SRH)and vitreous hemorrhage(VH).The risk factors for SRH include a long duration,clustered PCV,non-regression of polyp lesions and presented with retinal pigment epithelial detachment.The treatments for SRH including anti-vascular endothelial growth factor drugs,photodynamic therapy,laser,vitreous pneumatic displacement,intravenously injected tissue plasminogen activator,vitrectomy and combination therapy.Whether macular fovea is involved and the time since bleeding onset are the main factors affecting the choice of treatment for SRH.Older age of onset,higher white blood cell count,higher aspartate amino transferase and alanine amino transferase ratio,longer activated partial thromboplastin time retinal pigment epithelium detachment,photodynamic therapy history,intravitreal injection history larger SRH area and presented with retinal pigment epithelial detachment were associated with higher risk of VH.PCV patients with massive VH should be treated with vitrectomy,while the timing and technique of operation should be paid attention to.At present,the risk factors of PCV massive bleeding are not completedly clear,and its treatment methods are diverse,which requires a large number of studies to prove its effectiveness and establish expert diagnosis and treatment consensus.关键词
息肉状脉络膜血管病变/视网膜下出血/玻璃体积血/综述Key words
polypoidal choroidal vasculopathy/subretinal hemorrhage/vitreous hemorrhage/review引用本文复制引用
刘宝怡,马媛,李涛..息肉状脉络膜血管病变发生大出血的危险因素和治疗进展[J].眼科学报,2024,39(1):19-26,8.基金项目
国家自然科学基金(82070972,82271093) （82070972,82271093）
广州市科技重点研发项目(202103000045).This work was supported by the National Natural Science Foundation of China(82070972,82271093) （202103000045）
the Key Science&Technology Project of Guangzhou(202103000045),China. （202103000045）
