不同频率重复经颅磁刺激联合药物治疗癫痫的效果研究OA
Study on Effect of Different Frequencies of Repetitive Transcranial Magnetic Stimulation Combined with Drugs in the Treatment of Epilepsy
目的 探讨不同频率重复经颅磁刺激(rTMS)联合药物治疗癫痫的效果.方法 选取2020年3月至2021年3月本院收治的癫痫患者106例,随机分为观察组(53例,5.0 Hz频率rTMS联合药物)与对照组(53例,1.0 Hz频率rTMS联合药物).比较两组的疗效、脑电图指标、认知功能及生活质量.结果 观察组总有效率高于对照组(P＜0.05).治疗4周后,观察组脑电图尖波数量、尖波时程低于对照组(P＜0.05).治疗4周后,观察组简易精神状态量表(MMSE)及癫痫患者生活质量评定量表(QOLIE-31)评分均高于对照组(P＜0.05).结论 与1.0 Hz频率rTMS治疗比较,5.0 Hz频率rTMS联合药物治疗癫痫具有显著效果,能有效改善患者脑电图,提升认知功能及生活质量.
Objective To explore the effect of different frequencies of repetitive transcranial magnetic stimulation(rTMS)combined with drugs in the treatment of epilepsy.Methods 106 epilepsy patients admitted to our hospital from March 2020 to March 2021 were randomly divided into observation group(53 cases,5.0 Hz rTMS combined with drugs)and control group(53 cases,1.0 Hz rTMS combined with drugs).The efficacy,EEG indicators,cognitive function and quality of life were compared between groups.Results The total effective rate of the observation group was higher than that of the control group(P＜0.05).After 4 weeks of treatment,the EEG sharp wave number and sharp wave duration of the observation group were lower than those of the control group(P＜0.05).After 4 weeks of treatment,the scores of Mini Mental State Examination(MMSE)and the Quality of Life in Epilepsy(QOLIE-31)in the observation group were higher than those in the control group(P＜0.05).Conclusions Compared with 1.0 Hz rTMS,5.0 Hz rTMS combined with drugs has significant effect in the treatment of epilepsy,which can effectively improve patients'EEG,cognitive function and quality of life.
王丹慧;崔滨;孙丽霞;李青华;王松林;彭斐斐;于江涛;许自强
许昌市中心医院神经内科,河南许昌 461000航空总医院神经外科,北京 100012
临床医学
不同频率重复经颅磁刺激癫痫脑电图
Different frequenciesRepetitive transcranial magnetic stimulationEpilepsyElectroencephalogram
《临床医学工程》 2024 (005)
529-530 / 2
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