中国当代儿科杂志2024，Vol.26Issue(4)：403-409,7.DOI:10.7499/j.issn.1008-8830.2310102
高海拔地区健康足月新生儿脑氧代谢及脑电活动差异的多中心临床研究方案
Cerebral oxygen metabolism and brain electrical activity of healthy full-term neonates in high-altitude areas:a multicenter clinical research protocol
摘要
Abstract
Further evidence is needed to explore the impact of high-altitude environments on the neurologic function of neonates.Non-invasive techniques such as cerebral near-infrared spectroscopy and amplitude-integrated electroencephalography can provide data on cerebral oxygenation and brain electrical activity.This study will conduct multiple cerebral near-infrared spectroscopy and amplitude-integrated electroencephalography monitoring sessions at various time points within the first 3 days postpartum for healthy full-term neonates at different altitudes.The obtained data on cerebral oxygenation and brain electrical activity will be compared between different altitudes,and corresponding reference ranges will be established.The study involves 6 participating centers in the Chinese High Altitude Neonatal Medicine Alliance,with altitude gradients divided into 4 categories:800 m,1 900 m,2 400 m,and 3 500 m,with an anticipated sample size of 170 neonates per altitude gradient.This multicenter prospective cohort study aims to provide evidence supporting the impact of high-altitude environments on early brain function and metabolism in neonates.[Chinese Journal of Contemporary Pediatrics,2024,26(4):403-409]关键词
近红外光谱/脑组织氧饱和度/振幅整合脑电图/高原/新生儿Key words
Near-infrared spectroscopy/Cerebral oxygenation/Amplitude-integrated electroencephalography/High altitude/Neonate引用本文复制引用
泽碧,杨永礼,和春叶,赵燕,杜琨,刘玲,周文浩,中国高原新生儿医学联盟,高瑾,赵晓芬,李杨方,张铁松,刘晓梅,毛辉,秦明彩,张奕..高海拔地区健康足月新生儿脑氧代谢及脑电活动差异的多中心临床研究方案[J].中国当代儿科杂志,2024,26(4):403-409,7.基金项目
[基金项目]国家自然科学基金资助项目(82060291) （82060291）
云南省周文浩专家工作站(20191C052). （20191C052）
