中国当代儿科杂志2024，Vol.26Issue(4)：425-431,7.DOI:10.7499/j.issn.1008-8830.2310076
生物信息学在肺动脉高压中的研究进展
Research progress on bioinformatics in pulmonary arterial hypertension
摘要
Abstract
Pulmonary arterial hypertension(PAH)is a severe disease characterized by abnormal pulmonary vascular remodeling and increased right ventricular pressure load,posing a significant threat to patient health.While some pathological mechanisms of PAH have been revealed,the deeper mechanisms of pathogenesis remain to be elucidated.In recent years,bioinformatics has provided a powerful tool for a deeper understanding of the complex mechanisms of PAH through the integration of techniques such as multi-omics analysis,artificial intelligence,and Mendelian randomization.This review focuses on the bioinformatics methods and technologies used in PAH research,summarizing their current applications in the study of disease mechanisms,diagnosis,and prognosis assessment.Additionally,it analyzes the existing challenges faced by bioinformatics and its potential applications in the clinical and basic research fields of PAH in the future.[Chinese Journal of Contemporary Pediatrics,2024,26(4):425-431]关键词
肺动脉高压/生物信息学/人工智能/机器学习Key words
Pulmonary arterial hypertension/Bioinformatics/Artificial intelligence/Machine learning引用本文复制引用
彭威,张泽盈,肖云彬..生物信息学在肺动脉高压中的研究进展[J].中国当代儿科杂志,2024,26(4):425-431,7.基金项目
国家自然科学基金(81500041) （81500041）
湖南省儿童心血管病临床医学研究中心(2021SK4019) （2021SK4019）
湖南省研究生科研创新项目(CX20231013). （CX20231013）
