中国临床药学杂志2024，Vol.33Issue(1)：11-17,7.DOI:10.19577/j.1007-4406.2024.01.002
上海地区汉族2型糖尿病患者的降糖药物相关基因多态性研究
Genetic polymorphism related to hypoglycemic drugs in Han Chinese patients with type 2 diabetes in Shanghai
摘要
Abstract
AIM To explore the genetic polymorphisms related to oral hypoglycemic drugs in Han patients with type 2 diabetes mellitus(T2DM)in Shanghai,and to provide a reference for individualized drug therapy for T2DM patients.METHODS Data on 70 Shanghai Han patients with T2DM treated at Gongli Hospital in the Pudong New District of Shanghai from August 2021 to December 2022 were collected.Nucleic acid mass spectrometry was used to identify polymorphisms in 14 genes associated with 6 types of hypoglycemic drugs,and the allele and genotype frequencies were statistically analyzed.RESULTS The genotype frequencies of hypoglycemic drug-related genes in 70 Han Chinese patients with T2DM in Shanghai were in accordance with the Hardy-Weinberg equilibrium,and the allele distribution frequencies showed no significant statistical difference compared to the Chinese general population(P＞0.05).However,there were gender differences in the C11orf65(rs1 1212617)gene(P＜0.05).In addition,there were statistically significant differences in glycosylated hemoglobin(HBA1c)among patients with different genotypes of PPARγ(rs1801282),ADIPOQ(rs2241766),C11orf65(rs1 1212617),KCNQ1(rs2237892)and IGF2BP2(rs1470579).CONCLUSION The distribution of gene polymorphism related to hypoglycemic drugs in Han Chinese T2DM patients in Shanghai is similar to that of the Chinese population.It is necessary for clinicians to conduct pharmacogenetic detection before prescribing biguanides,non-sulfonylureas and thiazolidinediones to facilitate precision medicine in clinical practice.关键词
降糖药物/基因多态性/2型糖尿病Key words
hypoglycemic drug/gene polymorphism/type 2 diabetes mellitus引用本文复制引用
董婧,刘瑾瑶,阚悦,陆燕,李文艳..上海地区汉族2型糖尿病患者的降糖药物相关基因多态性研究[J].中国临床药学杂志,2024,33(1):11-17,7.基金项目
上海市浦东新区卫生健康委员会个体化精准药物治疗(编号PWZy2020-11) （编号PWZy2020-11）
