中国临床药理学杂志2024，Vol.40Issue(8)：1111-1115,5.DOI:10.13699/j.cnki.1001-6821.2024.08.005
瑞马唑仑与丙泊酚对肺癌电视胸腔镜手术患者的麻醉效果研究
Anesthetic effect of remimazolam and propofol in patients underwent video-assisted thoracoscopic surgery for lung cancer
姚晶曼 1胡友洋 1张欢欢 1孔婧 1孟璐 1李若男 1董喆1
作者信息
- 1. 安徽省胸科医院麻醉科,安徽合肥 230032
- 折叠
摘要
Abstract
Objective To compare the anesthetic effect and safety of remimazolam and propofol on patients underwent video-assisted thoracoscopic surgery for lung cancer.Methods Clinical data of patients with lung cancer underwent video-assisted thoracoscopic surgery were retrospectively collected.Remimazolam group was anesthetized by remimazolam,and propofol group was anesthetized by propofol.The changes in mean arterial pressure(MAP)and heart rate(HR)were compared between the two groups of patients before anesthesia induction(T0),after 5 min of tracheal intubation(T1),after 1 h of surgery(T2),during thorax closure(T3)and at 5 min after extubation(T4).The sedation onset time,recovery time and extubation time in the two groups were recorded.Stress response indicators[adrenocorticotropic hormone(ACTH),cortisol(Cor)]were compared at T0 and T4.Ramsay sedation score(RSS)was used to assess the sedation degree at T4.Visual analogue score(VAS)was applied to evaluate the pain degree at 2,12 and 24 h after surgery,and the perioperative anaesthesia-related adverse events were observed.Results There were 58 cases in remimazolam group and 64 cases in propofol group.The MAP values at T1 in remimazolam group and propofol group were(85.03±4.37)and(78.24±4.48)mmHg;at T2 were(80.39±3.95)and(75.49±4.11)mmHg;at T3 were(84.43±4.02)and(79.59±3.97)mmHg;the HR values at T2 were(76.44±5.75)and(72.39±6.03)beat·min-1,the difference were all significant(all P＜0.05).The sedation onset times in remimazolam group and propofol group were(62.45±6.27)and(72.33±7.19)s;the recovery times were(7.22±1.23)and(8.24±1.48)min;the extubation times were(8.34±1.50)and(10.09±1.83)min;the RSS scores at T4 were(2.03±0.39)and(1.88±0.35)points,the difference were all significant(all P＜0.05).The total incidence rates of anesthesia-related adverse events in remimazolam group and propofol group were 6.90％and 21.88％,respectively(P＜0.05).Conclusion Both remimazolam and propofol can play a good sedative effect during lung cancer video-assisted thoracoscopic surgery anesthesia.Remimazolam anesthesia has more stable intraoperative hemodynamics,faster onset and elimination,and higher safety.关键词
瑞马唑仑/丙泊酚/电视胸腔镜/肺癌/镇静Key words
remimazolam/propofol/video-assisted thoracoscopy/lung cancer/sedation分类
医药卫生引用本文复制引用
姚晶曼,胡友洋,张欢欢,孔婧,孟璐,李若男,董喆..瑞马唑仑与丙泊酚对肺癌电视胸腔镜手术患者的麻醉效果研究[J].中国临床药理学杂志,2024,40(8):1111-1115,5.
