中国临床药学杂志2024，Vol.33Issue(1)：30-35,6.DOI:10.19577/j.1007-4406.2024.01.005
蒙特卡洛模拟法优化舒巴坦在重症连续性静脉-静脉血液滤过患者的给药方案研究
Optimization of sulbactam regimens in intensive care unit continuous veno-venous hemofiltration patients with Monte Carlo simulation method
摘要
Abstract
AIM To optimize sulbactam regimens for intensive care unit(ICU)continuous veno-venous hemofiltration(CVVH)patients using the Monte Carlo simulation method.METHODS Pharmacokinetic/pharmacodynamic(PK/PD)parameters of sulbactam in ICU CVVH patients and the minimum inhibitory concentration(MIC)of Acinetobacter baumannii(AB)were collected.Monte Carlo simulations(n=5 000)were conducted to assess the rationality of the dosing regimen.The PK/PD target values for AB were 40％fT＞MIC and 60％fT＞MIC.RESULTS For ICU patients with CVVH caused by AB,when the MIC was 4 mg·L-1,the recommended dosing regimens were traditional intravenous infusions of 1 g,q8h and 1 g,q6h(with each dose infused over 0.5 h).The empiric dosing regimens recommended under 2 PK/PD target values were 24-hour continuous intravenous infusion of 9 g,q24h and 12 g,q24h.CONCLUSION It is recommended to use either a 3-hour extended intravenous infusion or a 24-hour continuous intravenous infusion regimen for the treatment of AB strains with lower susceptibility.关键词
药动学/药效学/舒巴坦/蒙特卡洛模拟/重症/血液滤过/鲍曼不动杆菌Key words
pharmacokinetic/pharmacodynamic/sulbactam/Monte Carlo method/continuous venovenous hemofiltration/Acinetobacter baumannii引用本文复制引用
李颖,余佩,薛飞,陈敏纯,王登,董亚琳..蒙特卡洛模拟法优化舒巴坦在重症连续性静脉-静脉血液滤过患者的给药方案研究[J].中国临床药学杂志,2024,33(1):30-35,6.基金项目
陕西省自然科学基础研究计划青年基金(编号2019JQ-475) （编号2019JQ-475）
西安市第三医院国科金青年培训项目(编号Y2023qn0008) （编号Y2023qn0008）
