中国药房2024，Vol.35Issue(9)：1139-1144,6.DOI:10.6039/j.issn.1001-0408.2024.09.20
沙利度胺联合CAG方案治疗老年急性髓系白血病患者有效性与安全性的Meta分析
Meta-analysis on efficacy and safety of thalidomide combined with CAG regimen in the treatment of elderly patients with acute myeloid leukemia
摘要
Abstract
OBJECTIVE To systematically evaluate the efficacy and safety of thalidomide combined with aclacinomycin,granulocyte colony-stimulating factor and cytarabine(CAG)regimen in the treatment of elderly patients with acute myeloid leukemia(AML).METHODS CNKI,Wanfang data,VIP,Sino Med,PubMed,Embase,the Cochrane Library and Web of Science were searched comprehensively from the inception to Aug.27th,2023.Randomized controlled trials(RCTs)about thalidomide combined with CAG regimen(trial group)versus CAG regimen(control group)in the treatment of elderly AML patients were collected,and RevMan 5.3 software was used for meta-analysis of included studies.RESULTS Finally,7 RCTs were included,with a total of 601 patients,including 307 patients in the trial group and 294 patients in the control group.Meta-analysis results showed that the trial group was superior to the control group in enhancing the overall response rate[Z=4.75,P＜0.000 01,OR=2.80,95%CI(1.83,4.28)],complete remission rate[Z=2.82,P=0.005,OR=1.61,95%CI(1.16,2.25)],and improving platelet count[Z=2.70,P=0.007,MD=64.02,95%CI(17.53,110.51)],vascular endothelial growth factor[Z=13.63,P＜0.000 01,MD=-65.17,95%CI(-74.54,-55.80)],vascular endothelial growth factor receptor[Z=12.03,P＜0.000 01,MD=-499.01,95%CI(-580.31,-417.71)]and basic fibroblast growth factor[Z=4.17,P＜0.000 1,MD=-0.23,95%CI(-0.35,-0.12)].And there was no statistical difference between the trial group and the control group in the incidence of adverse drug reaction[Z=0.99,P=0.32,OR=0.52,95%CI(0.14,1.89)],nausea and vomiting[Z= 1.06,P=0.29,OR=0.66,95%CI(0.30,1.43)],constipation or diarrhea[Z=0.92,P=0.36,OR=0.65,95%CI(0.26,1.63)],drowsiness[Z=1.38,P=0.17,OR=0.57,95%CI(0.26,1.27)]or myelosuppression[Z=0.88,P=0.38,OR=0.68,95%CI(0.28,1.62)].CONCLUSIONS The combination of thalidomide and CAG regimen in the treatment of elderly AML patients can significantly improve clinical efficacy and has high safety.关键词
沙利度胺/阿克拉霉素/粒细胞集落刺激因子/阿糖胞苷/急性髓系白血病/老年患者/Meta分析Key words
thalidomide/aclacinomycin/granulocyte colony-stimulating factor/cytarabine/acute myeloid leukemia/elderly patients/meta-analysis分类
医药卫生引用本文复制引用
李晓靖,胡琦,陆嘉惠,刘敏,邓剑青,江雯雯,鲍计章..沙利度胺联合CAG方案治疗老年急性髓系白血病患者有效性与安全性的Meta分析[J].中国药房,2024,35(9):1139-1144,6.基金项目
国家自然科学基金项目(No.81774258) （No.81774258）
上海市科技计划项目(No.23Y11921300,No.22Y11921100) （No.23Y11921300,No.22Y11921100）
上海市中医医院中医药传承人才培育项目(No.WLJH2021ZY-MZY033) （No.WLJH2021ZY-MZY033）
上海市中医医院中医药科技发展项目(No.WL-XJRY-2021004K) （No.WL-XJRY-2021004K）
中国民族医药学会科研项目(No.2020ZY366-440401) （No.2020ZY366-440401）
