中药复方及有效成分对精神分裂症的改善机制研究进展OA北大核心CSTPCD

Schizophrenia has various obstacles in cognition,thinking,emotion,behavior and other aspects;it belongs to the category of"madness"in traditional Chinese medicine(TCM).Once schizophrenia occurs,multiple factors are often intertwined,and a single therapy is difficult to be effective.At present,TCM compounds and active ingredients have significant effects in the clinical treatment of schizophrenia,which is an important direction for the development of new drugs for schizophrenia.This article summarizes the molecular mechanism of TCM compounds and active ingredients in the treatment of schizophrenia.It is found that Wendan decoction and Yudian decoction can inhibit the apoptosis of hippocampal cells by activating BDNF/TrKB/CREB signaling pathway;quercetin and icariin can promote neural development and regeneration by activating NMDA/ERK signaling pathway;Wendan decoction and icariin can maintain neural cell homeostasis by activating PI3K/AKT signaling pathway;Bushen zhuangyang capsule can enhance learning and memory abilities by activating CaMKⅡ signaling pathway;formulas such as Huatan huoxue tongzhi formula can enhance intercellular information transmission by inhibiting PKC signaling pathway;α-humulene and others can restore nerve cell function by inhibiting NRG1/ErbB4 signaling pathway.TCM compounds and active ingredients can improve schizophrenia by intervening in the above-mentioned signaling pathways.