中国药房2024，Vol.35Issue(9)：1151-1156,6.DOI:10.6039/j.issn.1001-0408.2024.09.22
中药复方及有效成分对精神分裂症的改善机制研究进展
Research progress on the improvement mechanism of traditional Chinese medicine compounds and active ingredients in schizophrenia
摘要
Abstract
Schizophrenia has various obstacles in cognition,thinking,emotion,behavior and other aspects;it belongs to the category of"madness"in traditional Chinese medicine(TCM).Once schizophrenia occurs,multiple factors are often intertwined,and a single therapy is difficult to be effective.At present,TCM compounds and active ingredients have significant effects in the clinical treatment of schizophrenia,which is an important direction for the development of new drugs for schizophrenia.This article summarizes the molecular mechanism of TCM compounds and active ingredients in the treatment of schizophrenia.It is found that Wendan decoction and Yudian decoction can inhibit the apoptosis of hippocampal cells by activating BDNF/TrKB/CREB signaling pathway;quercetin and icariin can promote neural development and regeneration by activating NMDA/ERK signaling pathway;Wendan decoction and icariin can maintain neural cell homeostasis by activating PI3K/AKT signaling pathway;Bushen zhuangyang capsule can enhance learning and memory abilities by activating CaMKⅡ signaling pathway;formulas such as Huatan huoxue tongzhi formula can enhance intercellular information transmission by inhibiting PKC signaling pathway;α-humulene and others can restore nerve cell function by inhibiting NRG1/ErbB4 signaling pathway.TCM compounds and active ingredients can improve schizophrenia by intervening in the above-mentioned signaling pathways.关键词
精神分裂症/中药复方/中药有效成分/分子机制/信号通路Key words
schizophrenia/traditional Chinese medicine compound/active ingredients of traditional Chinese medicine/molecular mechanisms/signaling pathways分类
医药卫生引用本文复制引用
姚欣卉,赵永厚,柴剑波,于明,曲秀杰..中药复方及有效成分对精神分裂症的改善机制研究进展[J].中国药房,2024,35(9):1151-1156,6.基金项目
国家自然科学基金项目(No.82374438,No.81973747) （No.82374438,No.81973747）
黑龙江省中医药科研项目(No.ZHY2022-050,No.ZHY2023-132) （No.ZHY2022-050,No.ZHY2023-132）
