中国药科大学学报2024，Vol.55Issue(2)：194-201,8.DOI:10.11665/j.issn.1000-5048.2023112302
整合应激反应在中枢神经系统疾病中的研究进展
Research progress of integrated stress response in central nervous system diseases
摘要
Abstract
Integrated stress response is an adaptive response produced by eukaryotic cells after intracellular and extracellular stimulation.The activation of integrated stress response inhibits the translation of most proteins,yet it can promote the translation of certain proteins to cope with complex cellular microenvironment changes.A large number of studies have found that in a variety of nervous system diseases,the integrated stress response can be activated by stress signals of disease-related cells and participates in the occurrence and progression of diseases through processes such as learning and memory consolidation,myelin regeneration and synaptic plasticity.This article summarizes the role,mechanism and possible drug targets of integrated stress response in central nervous system diseases and discusses the potential of pharmacological methods to regulate integrated stress response in the treatment of central nervous system diseases,in order to provide reference for pathological research on and drug development for central nervous system diseases.关键词
阿尔茨海默病/缺血性卒中/创伤性脑损伤/整合应激反应/整合应激调节剂Key words
Alzheimer's disease/ischemic stroke/traumatic brain injury/integrated stress response/modulators of integrated stress分类
医药卫生引用本文复制引用
兰艾丽,刘刚,吴超然,廖红..整合应激反应在中枢神经系统疾病中的研究进展[J].中国药科大学学报,2024,55(2):194-201,8.基金项目
This study was supported by the National Natural Science Foundation of China(No.82073831,No.82372577) 国家自然科学基金项目(No.82073831,No.82372577) （No.82073831,No.82372577）
