立他司特滴眼液处方工艺优化及对干眼症疗效评价OA北大核心CSTPCD
Optimization of prescription process of lifitegrast eye drops and evaluation of its efficacy for dry eye disease
为了研制更有效的用于治疗干眼症的药物,进行了立他司特滴眼液的制备研究,并进行了体内外的安全性和有效性考察.首先开发了滴眼液中立他司特的含量测定方法.通过文献调研及单因素实验确定了制剂的处方组成和制备工艺.最后通过Draize眼刺激性试验和HE染色进行滴眼液安全性评价,以泪液分泌试验及ELISA试验评价其对于干眼兔的治疗有效性.结果表明,立他司特滴眼液的最终处方组成为立他司特 5%、氯化钠 0.4%、无水磷酸氢二钠 0.3%～0.4%、五水硫代硫酸…查看全部>>
In order to develop a more effective drug for dry eye disease,the preparation of lifitegrast eye drops was carried out,and the safety and efficacy of lifitegrast eye drops in vitro and in vivo were investigated.First the method for the determination of lifitegrast content was established,and then the composition and preparation process of the preparation were determined by literature review and single factor experiment.Finally,the safety of lifitegrast eye d…查看全部>>
颜喜;潘宇南;王锴莉;徐千姿;沈雁;陆洋
北京中医药大学中药学院制药系,北京 102488广州市药品检验所,广州 510160中国药科大学药学院药剂系,南京 211198中国药科大学药学院药剂系,南京 211198中国药科大学药学院药剂系,南京 211198北京中医药大学中药学院制药系,北京 102488
药学
立他司特制备工艺方法学体内外评价干眼症
lifitegrastpreparation processmethodologyin vivo-in vitro evaluationdry eye disease
《中国药科大学学报》 2024 (2)
基于中医阴阳理论构建“蟾酥—牛黄”药对有效成分粒径可变纳米递药系统并联合光动力调控肿瘤免疫微环境的探索和实践
209-216,8
国家自然科学基金项目(No.82173989) This study was supported by the National Natural Science Foundation of China(No.82173989)
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