Abstract
Objective To analyze the diagnostic value of combined detection of plasma B-type natriuretic peptide(BNP),creatine kinase-MB(CK-MB),troponin T(TNT),and myoglobin(MYO)in patients with acute myocardial infarction(AMI).Methods A total of 98 AMI patients admitted to Zaozhuang Municipal Hospital from January 2021 to January 2023 were included in the observation group,and 86 healthy individuals without a history of heart disease who underwent physical examination at the same time were included in the healthy group.The plasma BNP,CK-MB,TNT,and MYO between the two groups were detected.Additionally,the receiver operating characteristic(ROC)curve was drawn and the values of BNP,CK-MB,TNT,and MYO alone or in combination for diagnosing AMI were analyzed.Results In the observation group,BNP was(48.63±5.95)pmol/L,CK-MB was(46.95±5.24)U/L,TNT was(0.83±0.15)μg/L,and MYO was(99.84±8.69)ng/ml,higher than(19.83±2.51)pmol/L,(10.56±1.89)U/L,(0.15±0.02)μg/L,and(45.31±3.57)ng/ml in the healthy group,with statistically significant differences(P<0.05).The ROC curve results showed that the area under the curve(AUC)of BNP,CK-MB,TNT,and MYO in combination for diagnosing AMI was 0.918(95%CI[0.870,0.967],sensitivity=100.00%,specificity=87.20%),higher than 0.809(95%CI[0.737,0.881],sensitivity=91.80%,specificity=68.60%),0.810(95%CI[0.740,0.880],sensitivity=89.80%,specificity=69.80%),0.864(95%CI[0.803,0.925],sensitivity=96.90%,specificity=75.60%)and 0.854(95%CI[0.796,0.911],sensitivity=94.90%,specificity=70.90%)of BNP,CK-MB,TNT,and MYO alone for diagnosing AMI.Conclusion BNP,CK-MB,TNT,and MYO in the plasma of AMI patients are abnormally high in expression.The combined detection of the four can effectively diagnose AMI,provide certain reference information for clinical practice,and timely develop personalized treatment measures for patients to ensure excellent prognosis.关键词
急性心肌梗死/B型钠尿肽/肌酸激酶同工酶/肌钙蛋白/肌红蛋白Key words
Acute myocardial infarction/B-type natriuretic peptide/Creatine kinase-MB/Troponin/Myoglobin分类
医药卫生
