中国中医药图书情报杂志2024，Vol.48Issue(3)：50-55,6.DOI:10.3969/j.issn.2095-5707.202302097
基于数据挖掘探讨《医方考》含半夏处方用药规律
Discussion on the Medication Law of Prescriptions with Pinelliae Rhizoma in Yi Fang Kao Based on Data Mining
摘要
Abstract
Objective To explore the medication law of the prescriptions containing Pinelliae Rhizoma in Yi Fang Kao.Methods The prescriptions containing Pinelliae Rhizoma were collected from the Yi Fang Kao.Traditional Chinese Medicine Inheritance Calculation Platform 3.0,SPSS Statistics 27.0,and SPSS Modeler 18.0 software were used to conduct dose-response analysis,compatibility statistics,frequency statistics,correlation analysis,and clustering analysis on prescriptions.Results A total of 63 prescriptions were included,among which the average dosage of Pinelliae Rhizoma was 36.5 g.Most of them used prepared Pinelliae Rhizoma to reduce the toxicity;medicines for tonic,qi-regulating,exterior-relieving,heat-clearing,diuretic and dampness-reducing,phlegm-resolving and cough-relieving medicines showed high compatibility frequency with Pinelliae Rhizoma.The high-frequency drugs were Glycyrrhizae Radix et Rhizoma(45 times),Citri Reticulatae Pericarpium(33 times),Poria(28 times),Ginseng Radix et Rhizoma(25 times),etc.The association rules and core compatibility combinations found that the correlation of Pinelliae Rhizoma-Citri Reticulatae Pericarpium-Poria and Pinelliae Rhizoma-Ginseng Radix et Rhizoma-Glycyrrhizae Radix et Rhizoma were strong;K-means cluster analysis resulted in 3 clusters:①Pinelliae Rhizoma,Glycyrrhizae Radix et Rhizoma,Ginseng Radix et Rhizoma,Zingiberis Rhizoma and Rehmannine Radix;② Pinelliae Rhizoma,Glycyrrhizae Radix et Rhizoma,Citri Reticulatae Pericarpium,Poria and Atractylodis Macrocephalae Rhizoma;③Pinelliae Rhizoma,Glycyrrhizae Radix et Rhizoma,Zingiberis Rhizoma Recens,Ginseng Radix et Rhizoma andScutellariae Radix.Conclusion Among the prescriptions in Yi Fang Kao,Pinelliae Rhizoma is mostly compatible with tonic drugs,qi-regulating drugs,exterior-removing drugs,heat-clearing drugs,diuretic and dampness-removing drugs,phlegm-reducing,cough-relieving and asthma-relieving drugs,etc.关键词
医方考/半夏/脾胃/量效关系/数据挖掘Key words
Yi Fang Kao/Pinelliae Rhizoma/spleen and stomach/dosage-effect relationship/data mining分类
医药卫生引用本文复制引用
刘容辰,魏文一,邢亚丹,李琳荣..基于数据挖掘探讨《医方考》含半夏处方用药规律[J].中国中医药图书情报杂志,2024,48(3):50-55,6.基金项目
省级名中医传承工作室建设项目(SXSMZYGZS172) （SXSMZYGZS172）
山西中医药大学2021年研究生创新创业项目(2021CX005) （2021CX005）
