十二指肠间质瘤预后危险因素分析及不同手术治疗方式的远期预后比较OACSTPCD

Objective To investigate the prognostic factors of duodenal gastrointestinal stromal tumor(duodenal GIST)and the long-term prognostic effects of different therapy methods.Methods The data of patients diagnosed with duodenal GIST from 2000 to 2019 were extracted from SEER database and analyzed retrospectively.Multivariate Cox proportional hazards model was used to analyze the risk factors affecting the prognosis of patients,and Kaplan-Meier method was used to analyze the difference in long-term prognosis between the endoscopic resection group and the surgical resection group.Results 473 patients were included,with a median age of 59 years and a median tumor diameter of 50 mm.65.1%patients had localized disease when first diagnosed.390 patients(82.4%)received operative treatment,among which 46 patients(11.8%)received endoscopic treatment and 344 patients(88.2%)received surgical treatment.Multivariate Cox analysis showed that age＞73 years old,male,tumor diameter＞67 mm and distant metastasis were independent risk factors for cancer specific survival(CSS)in duodenal GIST patients(P＜0.05),receiving endoscopic or surgical treatment was an independent protective factor for CSS(P＜0.05).The long-term survival rates of endoscopic resection group and surgical resection group were similar(5 years CSS were 84.8%and 88.2%,10 years CSS were 80.1%and 80.6%,15 years CSS were 71.2%and 72.3%,P＞0.05).Conclusion Age＞73 years old,male,tumor diameter＞67 mm and distant metastasis are independent risk factors for prognosis of duodenal GIST.There is no significant difference in long-term survival rate between endoscopic resection treatment and surgical resection treatment.