中国医药科学2024，Vol.14Issue(7)：191-194,4.DOI:10.20116/j.issn2095-0616.2024.07.43
基于网络药理学对破格救心汤治疗急性心力衰竭主要活性成分及潜在靶点分析
Network pharmacological analysis of Poge Jiuxin Decoction in the treatment of acute heart failure
摘要
Abstract
Objective To analyze the main active ingredients and core target genes of Poge Jiuxin Decoction(PJD)in the treatment of acute heart failure(AHF)using network pharmacology research methods.Methods The effective active ingredients and target genes of(PJD)were obtained by traditional Chinese medicine systems pharmacology database and analysis platform(TCMSP),and AHF disease genes were collected through the Gene Cards database.Then,Venn analysis was performed on the drug action genes and disease-related genes to determine the intersection action targets of drugs,and then the intersection targets were taken for comprehensive analysis.Results The study found that the main active ingredients of Poge Jiuxin Decoction in the treatment of AHF were quercetin,kaempferol,sitosterol,naringin,ginsenoside-Rh2,etc.The key regulatory genes were caspase-3,Jun proto-oncogene,AP-1 transcription factor subunit,vascular endothelial growth factor A,interleukin-1β,tumor protein p53,estrogen receptor 1,interleukin-1,hypoxia inducible factor-1A,tumor necrosis factor,and aerine/threonine kinase-1.Conclusion The results of this study preliminarily explore the basic pharmacological effects and mechanisms of Poge Jiuxin Decoction in the treatment of AHF,and lay a good foundation for further test research.关键词
网络药理学/破格救心汤/急性心力衰竭/分子对接Key words
Network pharmacology/Poge Jiuxin Decoction/Acute heart failure/Molecular docking分类
医药卫生引用本文复制引用
张明,李光智,林道斌..基于网络药理学对破格救心汤治疗急性心力衰竭主要活性成分及潜在靶点分析[J].中国医药科学,2024,14(7):191-194,4.基金项目
海南省卫生计生行业科研项目(20A200278). （20A200278）
