中国医学创新2024，Vol.21Issue(11)：180-184,5.DOI:10.3969/j.issn.1674-4985.2024.11.039
双膦酸盐类药物相关性颌骨坏死的研究及进展
Research and Progress of Bisphosphonates Medication-related Osteonecrosis of the Jaw
梁宇豪1
作者信息
- 1. 德阳市人民医院口腔科 四川 德阳 618000
- 折叠
摘要
Abstract
Bisphosphonates(BPs)is clinical widely used in the prevention and treatment of osteoporosis and other diseases,and have achieved good therapeutic effect.However,a large number of reports have pointed out that BPs often cause medication-related osteonecrosis of the jaw(MRONJ)through anti-angiogenesis and inhibiting bone resorption.MRONJ is a serious adverse effect that may occur infrequently(e.g.following the oral administration of bisphosphonate treatments for osteoporosis)or frequently(e.g.following intravenous bisphosphonate for cancer treatment),depending on the dose and duration of use.At present,the pathological mechanism leading to jaw necrosis has not been fully clarified,and no consensus has been reached on the diagnosis and treatment of MRONJ.This paper summarized the research results on the pathogenesis and clinical treatment of MRONJ in recent years,and described the current research progress at home and abroad,to provide guidance and help for clinical application research.关键词
双膦酸盐/颌骨坏死/骨吸收/诊断标准/发病机制Key words
Bisphosphonate/Osteonecrosis of jaw/Bone resorption/Diagnostic criteria/Pathogenesis引用本文复制引用
梁宇豪..双膦酸盐类药物相关性颌骨坏死的研究及进展[J].中国医学创新,2024,21(11):180-184,5.
