中国医学创新2024，Vol.21Issue(12)：10-13,4.DOI:10.3969/j.issn.1674-4985.2024.12.003
瑞芬太尼复合七氟烷应用于剖宫产产妇的效果及对炎症细胞因子的影响
Effect of Remifentanil Combined with Sevoflurane in Parturient Undergoing Cesarean Section and Its Influence on Inflammatory Cytokines
摘要
Abstract
Objective:To explore the effect of Remifentanil combined with Sevoflurane in parturient underwent cesarean section and its influence on inflammatory cytokines.Method:A total of 90 parturients who underwent cesarean section in Huangzhou District People's Hospital of Huanggang City from January to December 2022 were randomly divided into experimental group(n=49)and control group(n=49).The control group was given Remifentanil combined with Propofol,and the experimental group was given Remifentanil combined with Sevoflurane.Hemodynamics,neonatal Apgar score,adverse reactions and inflammatory cytokine levels were compared between the two groups.Result:Compared with those before anesthesia,the mean arterial pressure and heart rate in both groups were increased at skin incision and the end of operation,but the mean arterial pressure and heart rate of the experimental group were lower than those of the control group,the differences were statistically significant(P<0.05).There were no significant differences in Apgar scores of newborns between experimental group and control group at 1,5 and 10 min after delivery(P>0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).On the first day after operation,the levels of various in inflammatory cytokines in both groups were increased,but the levels of hypersensitive C reactive protein,interleukin-6 and tumor necrosis factor-α in experimental group were lower than those in control group,the differences were statistically significant(P<0.05).Conclusion:Remifentanil combined with Sevoflurane has a significant effect in parturient undergoing cesarean section,which helps to maintain the hemodynamics and improve the levels of inflammatory cytokines,and has no obvious effect on the newborn,and the adverse reaction is less.关键词
瑞芬太尼/炎症细胞因子/剖宫产/七氟烷/不良反应Key words
Remifentanil/Inflammatory cytokines/Cesarean section/Sevoflurane/Adverse reactions引用本文复制引用
陈玲利,程海涛..瑞芬太尼复合七氟烷应用于剖宫产产妇的效果及对炎症细胞因子的影响[J].中国医学创新,2024,21(12):10-13,4.基金项目
湖北省卫生和计划生育委员会科研项目(WJ2017M244) （WJ2017M244）
