中国医药科学2024，Vol.14Issue(7)：4-7,29,5.DOI:10.20116/j.issn2095-0616.2024.07.01
手术治疗的肝细胞癌患者微血管侵犯的发生及其与预后的关系研究
Study on the occurrence of microvascular invasion in surgically-treated hepatocellular carcinoma patients and its relationship with prognosis
摘要
Abstract
Objective To investigate the occurrence of microvascular invasion(MVI)and its relationship with the prognosis of hepatocellular carcinoma(HCC)patients.Methods The clinical data of 1633 HCC patients who underwent surgical treatment from July 2015 to June 2022(305 from Shenzhen People's Hospital,591 from the First Affiliated Hospital of Nanchang University,578 from the Second Affiliated Hospital of Nanchang University,and 159 from Zhongshan City People's Hospital)was collected.The common independent influencing factors for prognosis and MVI of HCC patients were identified,and the incidence of MVI in different subgroups of influencing factors and its impact on patient prognosis were explored.Results The ROC curve showed that compared to other prognostic factors,MVI had the closest relationship with patient prognosis.Research showed that alpha fetoprotein(AFP),liver cirrhosis,tumor diameter and Lymphocyte-monocyte ratio(LMR)are common prognostic factors for MVI and HCC patients.After grouping,it was found that the incidence of MVI was significantly higher in patients with liver AFP-positive(AFP≥20 ng/ml),tumor diameter>50 mm,and LMR≤3.4 than patients in other groups,and MVI-positive patients in all four groups showed higher early recurrence rates and mortality rates(P<0.05).Conclusion Prognostic factors can effectively predict the occurrence of MVI and the relationship between MVI and prognosis in HCC patients after hepatectomy.关键词
微血管侵犯/肝细胞癌/肝切除术/预后因子Key words
Microvascular invasion/Hepatocellular carcinoma/Hepatectomy/Prognostic factors分类
医药卫生引用本文复制引用
杨继林,尹泽新,张文坚,崔理锋,吴美龙,刘利平..手术治疗的肝细胞癌患者微血管侵犯的发生及其与预后的关系研究[J].中国医药科学,2024,14(7):4-7,29,5.基金项目
广东省基础与应用基础研究基金(2021A1515220059). （2021A1515220059）
