中国医药科学2024，Vol.14Issue(7)：8-11,4.DOI:10.20116/j.issn2095-0616.2024.07.02
新型镁合金对金黄色葡萄球菌生物学特性影响的体外研究
In vitro study on the effect of a new magnesium alloy on the biological characteristics of Staphylococcus aureus
摘要
Abstract
Objective To explore the effect of a new magnesium alloy on the biological characteristics of Staphylococcus aureus.Methods There were two groups,an experimental group(with new magnesium alloy)and a control group(without new magnesium alloy)in the experiment,each with 3 replicate wells.Staphylococcus aureus proliferation experiment,Staphylococcus aureus plasma coagulase experiment,Staphylococcus aureus hemolysin experiment,and antibiotic antibacterial ring experiment were conducted respectively,and statistical analysis was performed after the experiments.Results The results of bacterial proliferation experiments showed that at the same time point,the OD values of the experimental group with different concentrations were significantly lower than those of the control group,with statistically significant differences(P<0.05).At different time points,the OD values of the experimental group at the same concentration were significantly lower than those of the control group(P<0.05).As the cultivation time prolonged,the difference in OD values between the experimental group and the control group at the same concentration gradually increased(P<0.05).The results of the Staphylococcus aureus plasma coagulase experiment showed that compared with the control group,the experimental group had smaller agglutination particles,and as the cultivation time prolonged,the agglutination particles gradually became smaller.The hemolysin test results of Staphylococcus aureus showed that compared with the control group,the β-hemolytic rings in the experimental group were relatively small and decreased with culture time,and after 7 days of cultivation,the β-hemolytic rings disappeared.The results of the antibiotic antibacterial ring experiment showed that compared with the control group,all antibiotics in the experimental group had larger inhibition ring diameters at days 1,3,5,and 7,with statistically significant differences(P<0.05).Conclusion Magnesium alloy has the ability to inhibit the proliferation of Staphylococcus aureus.At the same time,it also has impacts on its plasma coagulase,hemolysin,and antibiotic antibacterial properties.关键词
镁合金/金黄色葡萄球菌/生物学特性/生物膜Key words
Magnesium alloy/Staphylococcus aureus/Biological characteristics/Biofilm分类
农业科技引用本文复制引用
刘小荣,杨国清,梁文强,张玉娟,张鹏飞,张静,章晓波,王勇平..新型镁合金对金黄色葡萄球菌生物学特性影响的体外研究[J].中国医药科学,2024,14(7):8-11,4.基金项目
甘肃省兰州市科技计划项目(2021-1-79). （2021-1-79）
