中国医药科学2024，Vol.14Issue(7)：38-41,4.DOI:10.20116/j.issn2095-0616.2024.07.09
丙酮酸激酶M2型在非小细胞肺癌中的作用
The role of pyruvate kinase M2 in non-small cell lung cancer
摘要
Abstract
Lung cancer is one of the most common causes of death in the world,among which non-small cell lung cancer(NSCLC)accounts for 85%of all lung cancers.Pyruvate kinase(PK)is a key enzyme in glucose metabolism,which regulates the conversion rate of phosphoenolpyruvate to pyruvate.There are four subtypes,among which pyruvate kinase M2(PKM2)mainly exists in highly proliferative cells with high anabolic requirements,especially in tumors and embryonic tissues.PKM2 can regulate the aerobic glycolysis process of tumor cells and be transferred to the nucleus to participate in regulating the expression of various cancer-promoting factors.PI3K/AKT signaling pathway plays an important role in many biological processes such as cell growth,proliferation,differentiation,survival and metabolism.PKM2 can participate in the occurrence and development of NSCLC through the interaction with PI3K/AKT pathway.In this paper,the role of PKM2 in non-small cell lung cancer and its regulatory mechanism are reviewed.关键词
丙酮酸激酶M2型/非小细胞肺癌/能量代谢/AKT信号通路Key words
Pyruvate kinase M2/Non-small cell lung cancer/Energy metabolism/AKT signal pathway分类
医药卫生引用本文复制引用
徐江莉,宋新宇,郑红艳,熊晓琦,杨爱兰,李勋..丙酮酸激酶M2型在非小细胞肺癌中的作用[J].中国医药科学,2024,14(7):38-41,4.基金项目
湖北省中央引导地方科技发展专项(2022BCE031) （2022BCE031）
湖北省宜昌市医疗卫生研究项目(A22-2-003 （）
A19-301-11). （）
