中国医药科学2024，Vol.14Issue(7)：73-76,113,5.DOI:10.20116/j.issn2095-0616.2024.07.17
基于网络药理学和分子对接探讨益气定眩饮治疗脑梗死的作用机制
Discussion on the mechanism of Yiqi Dingxuan Decoction in treating cerebral infarction based on network pharmacology and molecular docking
摘要
Abstract
Objective To preliminarily explore the mechanism of Yiqi Dingxuan Decoction in treating cerebral infarction(CI)by using network pharmacology and molecular docking.Methods The potential targets and active components of Yiqi Dingxuan Decoction in the treatment of cerebral infarction were obtained and screened out through TCMSP database.CI-related targets were determined by using multiple databases and intersected with the potential targets of Yiqi Dingxuan Decoction,and the core targets of Yiqi Dingxuan Decoction in treating CI were obtained.The protein-protein interaction(PPI)network was constructed,and the gene ontology(GO)function enrichment analysis and the Kyoto encyclopedia of genes and genomes(KEGG)pathway enrichment analysis were carried out on the core targets through R language.Molecular docking technology was used to dock the main active components with the core targets.Results Yiqi Dingxuan Decoction contained 30 active components and 8 core targets acting on CI,which were involved in regulating immune response,tissue hypoxia,signal transduction and other signal pathways.The results of molecular docking showed that luteolin had good binding with tumor suppressor gene(TP53)and stigmasterol with caspase-3(CASP3).Conclusion Yiqi Dingxuan Decoction has the characteristics of multi targets and multi pathways in the treatment of cerebral infarction,which provides reference for the follow-up research.关键词
脑梗死/益气定眩饮/网络药理学/分子对接Key words
Cerebral infarction/Yiqi Dingxuan Decoction/Network pharmacology/Molecular docking分类
医药卫生引用本文复制引用
伍昌总,王思雨,张艺,张启,刘春华..基于网络药理学和分子对接探讨益气定眩饮治疗脑梗死的作用机制[J].中国医药科学,2024,14(7):73-76,113,5.基金项目
湖南省教育厅科学研究项目(22A0269) （22A0269）
湖南省中医药科研计划项目(201947) （201947）
湖南省研究生科研创新项目(CX20220818). （CX20220818）
