组织工程与重建外科杂志2024，Vol.20Issue(2)：248-253,6.DOI:10.3969/j.issn.1673-0364.2024.02.016
病理性瘢痕形成的细胞分子机制的研究进展
Advances in molecular mechanisms of pathological scar formation
摘要
Abstract
Fibrotic tissue called scar forms after the skin wound heals.Among them,pathological scars seriously affect the quality of life of patients because of their poor appearance and discomfort of pain and itching.However,the pathogenesis of pathological scar is still unclear,so there is a lack of effective animal models and clinical radical treatment.In this paper,the molecular mechanisms and interactions in the immune microenvironment of pathological scars were reviewed in order to provide references for the development of diagnostic markers and therapeutic targets for pathological scars and the optimization of tissue engineering construction.关键词
病理性瘢痕/分子机制/免疫微环境/皮肤纤维化/成纤维细胞Key words
Pathological scar/Molecular mechanism/Immune microenvironment/Skin fibrosis/Fibroblast分类
医药卫生引用本文复制引用
贾宇新,许恒,章一新..病理性瘢痕形成的细胞分子机制的研究进展[J].组织工程与重建外科杂志,2024,20(2):248-253,6.基金项目
上海交通大学医学院地高大双百人项目(20152227) （20152227）
上海市科学技术委员会临床医学研究中心项目(22MC1940300). （22MC1940300）
