中国现代医生2024，Vol.62Issue(12)：79-84,87,7.DOI:10.3969/j.issn.1673-9701.2024.12.018
益心健脾方"异病同治"冠心病和慢性心力衰竭网络药理学机制研究
Mechanisms of action of coronary heart disease and chronic heart failure by Yixin Jianpi prescription with the concept of"homotherapy for heteropathy"based on network pharmacology
摘要
Abstract
Objective Network pharmacology was used to explore the mechanism of action of Yixin Jianpi prescription in the treatment of coronary heart disease and chronic heart failure.Methods With the help of traditional Chinese medicine systems pharmacology(TCMSP),traditional Chinese medicine integrated database(TCMID)and other databases combined with literature data to screen the active ingredient targets of Yixin Jianpi prescription,the human gene database(GeneCards),online mendelian inheritance in man(OMIM)and other databases were used to search for disease targets.The STRING platform combines Cytoscape software to construct a"component-target-disease"network diagram and protein interaction network.Gene ontology(GO)functionality and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis using the DAVID database.The key components are taken and the target is molecularly docked with AutoDuck tools.Results 265 potential targets of Yixin Jianpi Prescription were obtained,and 106 of them were common targets of"homotherapy for heteropathy";The key active ingredients were quercetin,kaempferol,β-sitosterol,etc.and the core targets were SRC,AKT1,MAPK1,TP53,etc.Biological processes involve positive regulation of gene expression,negative regulation of apoptosis,signal transduction,etc.involving lipid and atherosclerosis,fluid shear stress,atherosclerosis and inflammatory response.Molecular docking verified the stable docking of key components quercetin and kaempferol with SRC,AKT1 and MAPK1 targets.Conclusion The study reveals the multi-component,multi-target,and multi-pathway mechanism of"homotherapy for heteropathy"of coronary heart disease and chronic heart failure by Yixin Jianpi prescription,and provides a basis for exploring its new clinical applications.关键词
网络药理学/异病同治/冠心病/慢性心力衰竭/分子对接Key words
Network pharmacology/Homotherapy for heteropathy/Coronary heart disease/Chronic heart failure/Molecular docking分类
医药卫生引用本文复制引用
金如意,陈启兰..益心健脾方"异病同治"冠心病和慢性心力衰竭网络药理学机制研究[J].中国现代医生,2024,62(12):79-84,87,7.基金项目
杭州市医药卫生科技项目(ZD20230115) （ZD20230115）
